Implantation of Cryopreserved Human Placental Fragments Restores Prooxidant-Antioxidant Balance in Experimental Animals of Late Ontogeny

Authors

  • Olga S. Prokopyuk Institute for Problems of Cryobiology and Cryomedicine of the National Academy of Sciences of Ukraine, Kharkiv
  • Volodymyr Yu. Prokopyuk Institute for Problems of Cryobiology and Cryomedicine of the National Academy of Sciences of Ukraine, Kharkiv
  • Nana M. Pasieshvili Kharkiv Regional Clinical Perinatal Center, Kharkiv
  • Viktor V. Chyzhevskiy Institute for Problems of Cryobiology and Cryomedicine of the National Academy of Sciences of Ukraine, Kharkiv
  • Viktor Yu. Trifonov Interdepartmental Scientific Center for Cryobiology and Cryomedicine of the National Academy of Sciences, Academy of Medical Sciences, Ministry of Health Care of Ukraine, Kharkiv
  • Volodymyr G. Karpenko Kharkiv Medical Academy of Postgraduate Education of Ukraine, Kharkiv
  • Olga O. Loginova Kharkiv Medical Academy of Postgraduate Education of Ukraine, Kharkiv

DOI:

https://doi.org/10.15407/cryo27.01.061

Keywords:

cryopreserved bioobjects of placental origin, pro-and antioxidant system, aging, geriatrics

Abstract

The studies have shown that animals of late ontogeny had the misbalance in prooxidative-antioxidative system of blood serum, liver and gonads with shift to the proxidant activity. Nevertheless, the implantation of cryopreserved human placenta fragments to experimental animals increased the activity of endogenous antioxidant system and contributed to the correction of pathological changes associated with aging. Analysis of the findings indicated that the restoration processes occurred both at cell and organism levels. The use of cryopreserved placental fragments in pre-senile age led to a gradual diverse correction of senile involutions, and an increased activity of endogenous antioxidant system during their sanogenesis substantiated the perspective of preventive and therapeutic protocols to treat geriatric pathologies.

Probl Cryobiol Cryomed 2017; 27(1): 61–70

Author Biographies

Olga S. Prokopyuk, Institute for Problems of Cryobiology and Cryomedicine of the National Academy of Sciences of Ukraine, Kharkiv

Department of Cryobiology of Reproduction System

Volodymyr Yu. Prokopyuk, Institute for Problems of Cryobiology and Cryomedicine of the National Academy of Sciences of Ukraine, Kharkiv

Department of Cryobiology of Reproduction System

Nana M. Pasieshvili, Kharkiv Regional Clinical Perinatal Center, Kharkiv


Viktor V. Chyzhevskiy, Institute for Problems of Cryobiology and Cryomedicine of the National Academy of Sciences of Ukraine, Kharkiv

Low Temperature Bank of Biological Objects

Viktor Yu. Trifonov, Interdepartmental Scientific Center for Cryobiology and Cryomedicine of the National Academy of Sciences, Academy of Medical Sciences, Ministry of Health Care of Ukraine, Kharkiv


Volodymyr G. Karpenko, Kharkiv Medical Academy of Postgraduate Education of Ukraine, Kharkiv

 

 

Olga O. Loginova, Kharkiv Medical Academy of Postgraduate Education of Ukraine, Kharkiv


 

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Published

2017-03-25

How to Cite

Prokopyuk, O. S., Prokopyuk, V. Y., Pasieshvili, N. M., Chyzhevskiy, V. V., Trifonov, V. Y., Karpenko, V. G., & Loginova, O. O. (2017). Implantation of Cryopreserved Human Placental Fragments Restores Prooxidant-Antioxidant Balance in Experimental Animals of Late Ontogeny. Problems of Cryobiology and Cryomedicine, 27(1), 61–70. https://doi.org/10.15407/cryo27.01.061

Issue

Section

Cryomedicine, Clinical and Experimental Transplantology