Effect of Intraportal Administration of Cryopreserved Splenocytes on Thyroid Gland Tissue Allograft Survival

Authors

  • G. A. Bozhok Institute for Problems of Cryobiology and Cryomedicine of the National Academy of Sciences of Ukraine, Kharkov

Keywords:

thyroid gland, splenocytes, cryopreservation, allotransplantation, donor-specific tolerance

Abstract

The influence of intraportal introduction of cryopreserved splenocytes on the survival of thyroid tissue allograft was investigated. An acute allograft rejection after transplantation of thyroid tissue fragments in the absence of immunosuppressant for 35 days was established, whereas introduction of native splenocytes of donor’s origin into portal vein of the recipient’s liver 7 days prior to allotransplantation prolongs an allograft survival. This effect is not observed when using post-thaw splenocyte suspensions, probably due to the elimination of macrophages under the influence of cryopreservation factors.

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Published

2011-09-19

How to Cite

Bozhok, G. A. (2011). Effect of Intraportal Administration of Cryopreserved Splenocytes on Thyroid Gland Tissue Allograft Survival. Problems of Cryobiology and Cryomedicine, 21(3), 330–337. Retrieved from http://journal.cryo.org.ua/index.php/probl-cryobiol-cryomed/article/view/131

Issue

Section

Cryomedicine, Clinical and Experimental Transplantology