Therapy With Cryopreserved and Lyophilized Cord Blood Leukoconcentrates in Experimental Atopic Dermatitis

Authors

  • Hanna K. Koval Institute for Problems of Cryobiology and Cryomedicine of the National Academy of Sciences of Ukraine, Kharkiv
  • Olena D. Lutsenko Institute for Problems of Cryobiology and Cryomedicine of the National Academy of Sciences of Ukraine, Kharkiv https://orcid.org/0000-0003-3982-9687
  • Mykola O. Bondarovych Institute for Problems of Cryobiology and Cryomedicine of the National Academy of Sciences of Ukraine, Kharkiv https://orcid.org/0000-0001-7977-0283
  • Igor G. Grisha Institute for Problems of Cryobiology and Cryomedicine of the National Academy of Sciences of Ukraine, Kharkiv https://orcid.org/0000-0003-2875-910X
  • Larysa V. Sokil Institute for Problems of Cryobiology and Cryomedicine of the National Academy of Sciences of Ukraine, Kharkiv; Interdepartmental Scientific Center of Cryobiology and Cryomedicine of the National Academy of Sciences of Ukraine, Academy of Medical Sciences and Ministry of Health of Ukraine, Kharkiv https://orcid.org/0000-0002-8702-7374
  • Maksym V. Ostankov Institute for Problems of Cryobiology and Cryomedicine of the National Academy of Sciences of Ukraine, Kharkiv https://orcid.org/0000-0001-8412-5262
  • Anatoliy M. Goltsev Institute for Problems of Cryobiology and Cryomedicine of the National Academy of Sciences of Ukraine, Kharkiv; Interdepartmental Scientific Center of Cryobiology and Cryomedicine of the National Academy of Sciences of Ukraine, Academy of Medical Sciences and Ministry of Health of Ukraine, Kharkiv https://orcid.org/0000-0002-5289-5876

Keywords:

atopic dermatitis, cytokines, cryopreservation, lyophilization, human cord blood cells, prednisolone

Abstract

Probl Cryobiol Cryomed 2024; 34(4):282–286

Author Biographies

Hanna K. Koval, Institute for Problems of Cryobiology and Cryomedicine of the National Academy of Sciences of Ukraine, Kharkiv

Department of Cryopathophysiology and Immunology

Olena D. Lutsenko, Institute for Problems of Cryobiology and Cryomedicine of the National Academy of Sciences of Ukraine, Kharkiv

Department of Cryopathophysiology and Immunology

Mykola O. Bondarovych, Institute for Problems of Cryobiology and Cryomedicine of the National Academy of Sciences of Ukraine, Kharkiv

Department of Cryopathophysiology and Immunology

Igor G. Grisha, Institute for Problems of Cryobiology and Cryomedicine of the National Academy of Sciences of Ukraine, Kharkiv

Department of Cryopathophysiology and Immunology

References

Bereznyakova AI, Cheremisina VF, Zhemela OD. [Cellular and humoral immunity in rats with atopic dermatitis]. Fiziol. Zh. 2014; 60 (4): 50-5. Ukrainian. CrossRef PubMed

Goltsev AM, Sokil LV, Stetsyshyn VG, Mosiychuk VV, Bondarovych MO, Grisha IG, Ostankov MV, Lutsenko OD, Ostankova LV, Chernyshenko LH, inventors; Institute for Problems of Cryobiology and Cryomedicine of the NAS of Ukraine, patent owner. Method of lyophilization of cord blood leukoconcentrate. Patent of Ukraine No. 125846. 05/25/2018.

Jujo K, Renz H, Abe J, et al. Decreased interferon gamma and increased interleukin-4 production in atopic dermatitis promotes IgE synthesis. J Allergy Clin Immunol. 1992; 90(3 Pt 1): 323-31. CrossRef PubMed

Kallmann BA, Kolb H, Huther M, et al. Interleukin-10 is a predominant cytokine in atopic dermatitis. Arch Dermatol. 1996; 132(9):1133-4. CrossRef PubMed

Koval H, Bondarovych M, Goltsev A. [Cord blood as a corrector of hematological and cytomorphological characteristics of lymphohematopoietic organs in experimental atopic dermatitis]. Innov Biosyst Bioeng. 2023; 7(3): 3-20. Ukrainian. CrossRef

Koval HK, Lutsenko OD, Bondarovych MO, et al. [The role of cord blood in the regulation of cellular and humoral immunity in experimental atopic dermatitis]. Innov Biosyst Bioeng. 2021; 2021; 5 (3): 167-77. Ukrainian. CrossRef

Marks DJ, Radulovic M, McCartney S, et al. Modifi ed skin window technique for the extended characterisation of acute inflammation in humans. Inflamm Res. 2007; 56(4): 168-74. CrossRef PubMed

Tsutsayeva AO, Grishchenko VI, Kudokotseva OV, Shcheglov AV, Tupchienko GS, Prokopyuk OS. inventors; Institute for Problems of Cryobiology and Cryomedicine of the NAS of Ukraine, patent holder. Method of cryopreservation of hematopoietic cells of cord blood. Patent of Ukraine No. 31847A, 15.12.2000. 21.

Yamamura Y, Nakashima C, Otsuka A. Interplay of cytokines in the pathophysiology of atopic dermatitis: insights from Murin models and human. Front Med (Lausanne) [Internet]. 2024; 11: 1342176. Available from: https://www.frontiersin.org/journals/medicine/articles/10.3389/fmed.2024.1342176/full CrossRef PubMed

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Published

2025-04-04

How to Cite

Koval, H., Lutsenko, O., Bondarovych, M., Grisha, I., Sokil, L., Ostankov, M., & Goltsev, A. (2025). Therapy With Cryopreserved and Lyophilized Cord Blood Leukoconcentrates in Experimental Atopic Dermatitis. Problems of Cryobiology and Cryomedicine, 34(4), 282–286. Retrieved from http://journal.cryo.org.ua/index.php/probl-cryobiol-cryomed/article/view/2004

Issue

Vol. 34 No. 4 (2024): Probl Cryobiol Cryomed

Section

Short communications

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