Immunological Traits of Cryoablation in Combination Therapy of Cancer

Authors

  • Anatoliy M. Goltsev Institute for Problems of Cryobiology and Cryomedicine of the National Academy of Sciences of Ukraine, Kharkiv
  • Mykola O. Bondarovych Institute for Problems of Cryobiology and Cryomedicine of the National Academy of Sciences of Ukraine, Kharkiv
  • Tatiana G. Dubrava Institute for Problems of Cryobiology and Cryomedicine of the National Academy of Sciences of Ukraine, Kharkiv
  • Natalya M. Babenko Institute for Problems of Cryobiology and Cryomedicine of the National Academy of Sciences of Ukraine, Kharkiv
  • Yuliya O. Gaevska Institute for Problems of Cryobiology and Cryomedicine of the National Academy of Sciences of Ukraine, Kharkiv
  • Maksim V. Ostankov Institute for Problems of Cryobiology and Cryomedicine of the National Academy of Sciences of Ukraine, Kharkiv
  • Iryna A. Buriak Institute for Problems of Cryobiology and Cryomedicine of the National Academy of Sciences of Ukraine, Kharkiv

DOI:

https://doi.org/10.15407/cryo29.04.297

Keywords:

cryoablation, cancer stem cells, immune system, antigen, dendritic cells

Abstract

Cryoablation is a method of choice in treatment of solid tumors of different localization. In addition to the destruction of pathological tissue, the cryoablation causes to complex changes in the immune system. This paper briefly discusses the implementation of the abscopic effect after cryosurgery of tumors, as well as possible changes in the immune system that accompany it. The abscopic effect is achieved with a release of antigens from the destroyed cells, which trigger a cascade of immune reactions. This article summarizes the results of the combined use of cryoablation and immunotherapeutic methods, in particular adoptive therapy. The introduction of dendritic cells in combination with cryoablation can signiï¬cantly enhance antitumor immunity and reduces the risk of relapse.

 

Probl Cryobiol Cryomed 2019; 29(4): 297-302

Author Biographies

Anatoliy M. Goltsev, Institute for Problems of Cryobiology and Cryomedicine of the National Academy of Sciences of Ukraine, Kharkiv

Department of Cryopathophysiology and Immunology

Mykola O. Bondarovych, Institute for Problems of Cryobiology and Cryomedicine of the National Academy of Sciences of Ukraine, Kharkiv

Department of Cryopathophysiology and Immunology

Tatiana G. Dubrava, Institute for Problems of Cryobiology and Cryomedicine of the National Academy of Sciences of Ukraine, Kharkiv

Department of Cryopathophysiology and Immunology

Natalya M. Babenko, Institute for Problems of Cryobiology and Cryomedicine of the National Academy of Sciences of Ukraine, Kharkiv

Department of Cryopathophysiology and Immunology

Yuliya O. Gaevska, Institute for Problems of Cryobiology and Cryomedicine of the National Academy of Sciences of Ukraine, Kharkiv

Department of Cryopathophysiology and Immunology

Maksim V. Ostankov, Institute for Problems of Cryobiology and Cryomedicine of the National Academy of Sciences of Ukraine, Kharkiv

Department of Cryopathophysiology and Immunology

Iryna A. Buriak, Institute for Problems of Cryobiology and Cryomedicine of the National Academy of Sciences of Ukraine, Kharkiv

Department of Cryomicrobiology

References

Ahmedov SM, Rahimi FK, Ahmedov SSh, et al. [Application of cryogenic temperatures in liver surgery]. Reports of the Academician of Sciences of the Republic of Tajikistan. 2016, 59 (11-12): 524-33. Russian.

Benzon B, Glavaris SA, Simons BW, et al. Combining immune check-point blockade and cryoablation in an immunocompetent hormone sensitive murine model of prostate cancer. Prostate Cancer Prostatic Dis. 2018; 21(1): 126−36. CrossRef

Bayjoo P, Rees RC, Goepel JR, Jacob G. Natural killer cell activity following cryosurgery of normal and tumour bearing liver in an animal model. J Clin Lab Immunol. 1991; 35(3): 129-32. PubMed

Buriak I, Fleck R, Fuller B, Stacey G. The cryoprotectant DMSO. Identifying problems and developing its safe and effective use. In: Abstracts of the 55th SLTB Scientific Conference, Oct. 2-4, 2019, Seville, Spain. Seville; 2019. p. 46.

Campbell DE, Tustin NB, Riedel E, et al. Cryopreservation decreases receptor PD-1 and ligand PD-L1 coinhibitory expression on peripheral blood mononuclear cell-derived T cells and monocytes. Clin Vaccine Immunol. 2009; 16(11): 1648-53. CrossRef

Cha JH, Yang WH, Xia W, et al. Metformin promotes antitumor immunity via endoplasmic-reticulum-associated degradation of PD-L1. Mol Cell. 2018; 71(4): 606-20. CrossRef

El-Ashmawy NE, El-Zamarany EA, Salem ML, et al. A new strategy for enhancing antitumor immune response using dendritic cells loaded with chemo-resistant cancer stem-like cells in experimental mice model. Mol Immunol. 2019;111: 106-17. CrossRef

Gallucci S, Chakhtoura M, Lee MH, Qiu CC. The metabolic modulator metformin affects the activation and survival of murine dendritic cell subsets. J Immunol [Internet] . 2019 [Cited 18.01.2019]; 202(1 Suppl): 180.17 Available from: https://www.jimmunol.org/content/202/1_Supplement/180.17

Goltsev A, Bondarovich N, Babenko N, Gaevskaya Yu. Freezing conditions determine the integrity of antigenic characteristics of cancer cells. Experimental Oncology. 2018; 40 (2): 159.

Goltsev AN, Bondarovich NA, Babenko NN, et al. Freezing conditions determine functional potential of tumor cells. Cryobiology. 2018; 85: 168. CrossRef

Goltsev AM, Bondarovych MO, Babenko NM, et al. Effect of different cryopreservation regimens on Ehrlich carcinoma growth. Cell Tissue Bank. 2019; 20(3): 411-21. CrossRef

Goltsev AN, Safranchuk OV, Bondarovich NA, et al. [Change in cryolability of cancer stem cells during in vivo culture of Ehrlich adenocarcinoma]. Fiziol Zh. 2011; 57(4): 68-76. Ukranian. CrossRef

Gulley JL, Madan RA, Pachynski R et al. Role of antigen spread and distinctive characteristics of immunotherapy in cancer treatment. J Natl Cancer Inst [Internet]. 2017 [cited 19.11.2019]; 109(4): djw261. Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5441294/pdf/djw261.pdf CrossRef

Hamad GG, Neifeld JP. Biochemical, hematologic, and immunologic alterations following hepatic cryotherapy. Semin Surg Oncol. 1998; 14(2): 122-8. CrossRef

Li X, Zhong Z, Liang S, et al. Effect of cryopreservation on IL-4, IFNgamma and IL-6 production of porcine peripheral blood lymphocytes. Cryobiology. 2009; 59(3):322-6. CrossRef

Lleo A, Rimassa L, Colombo M. Hepatotoxicity of immune check point inhibitors: Approach and management. Dig Liver Dis. 2019; 51(8):1074-8. CrossRef

Mahmoodi S, Nezafat N, Negahdaripour M, Ghasemi Y. A new approach for cancer immunotherapy based on the cancer stem cell antigens properties. Curr Mol Med. 2019; 19(1): 2-11. CrossRef

Paczulla AM, Rothfelder K, Raffel S, et al Absence of NKG2D ligands defines leukaemia stem cells and mediates their immune evasion. Nature. 2019; 572(7768): 254-9. CrossRef

Robilotto AT, Baust JM, Van Buskirk RG, et al. Temperature-dependent activation of differential apoptotic pathways during cryoablation in a human prostate cancer model. Prostate Cancer Prostatic Dis. 2013; 16(1): 41-9. CrossRef

Sabel MS. Cryo-immunology: a review of the literature and proposed mechanisms for stimulatory versus suppressive immune responses. Cryobiology. 2009; 58(1): 1-11. CrossRef

Si TG, Wang JP, Guo Z. Analysis of circulating regulatory T cells (CD4+CD25+CD127-) after cryosurgery in prostate cancer. Asian J Androl. 2013;15(4):461-5. CrossRef

Sidana A. Cancer immunotherapy using tumor cryoablation. Immunotherapy. 2014; 6(1): 85-93. CrossRef

Soanes WA, Ablin RJ, Gonder MJ. Remission of metastatic lesions following cryosurgery in prostatic cancer: immunologic considerations. J Urol. 1970; 104(1): 154-9. CrossRef

Steinman RM, Cohn ZA. Identification of a novel cell type in peripheral lymphoid organs of mice. I. Morphology, quantitation, tissue distribution. J Exp Med. 1973; 137(5): 1142-62. CrossRef

Tan W, Tang H, Jiang X. et al. Metformin mediates induction of miR-708 to inhibit self-renewal and chemoresistance of breast cancer stem cells through targeting CD47. J Cell Mol Med. 2019; 23(9): 5994-6004. CrossRef

Vermaelen K. Vaccine strategies to improve anti-cancer cellular immune responses. Front Immunol [Internet]. 2019 [cited 19.11.2019]; 10:8. Available from: www.ncbi.nlm.nih.gov/pmc/articles/PMC6349827/pdf/fimmu-10-00008.pdf CrossRef

Vijendren A, Yung M, Sanchez J. Occupational health issues amongst UK doctors: a literature review. Occup Med (Lond). 2015; 65 (7): 519-28. CrossRef

Xu P, Yin K, Tang X, et al. Metformin inhibits the function of granulocytic myeloid-derived suppressor cells in tumor-bearing mice. Biomed Pharmacother [Internet]. 2019 [cited 07.11.2019]; 120: 109458. Available from: https://www.sciencedirect.com/science/article/pii/S0753332219336157 CrossRef

Yang X, Guo Y, Guo Z, et al. Cryoablation inhibition of distant untreated tumors (abscopal effect) is immune mediated. Oncotarget. 2018; 10(41): 4180-91. CrossRef

Downloads

Published

2019-12-17

How to Cite

Goltsev, A. M., Bondarovych, M. O., Dubrava, T. G., Babenko, N. M., Gaevska, Y. O., Ostankov, M. V., & Buriak, I. A. (2019). Immunological Traits of Cryoablation in Combination Therapy of Cancer. Problems of Cryobiology and Cryomedicine, 29(4), 297–302. https://doi.org/10.15407/cryo29.04.297