Influence of Application of Cryopreserved Placental Cell Suspension on Indices of Peripheral Blood and Bone Marrow of Animals With Adjuvant Arthritis
DOI:
https://doi.org/10.15407/cryo29.01.028Keywords:
arthritis, cryopreservation, placenta, hematopoietic stem cellsAbstract
In the model of adjuvant-induced arthritis in CBA/H mice there were investigated the gematological indices, circulating immune complexes (CIC) in peripheral blood, a number of hematopoietic stem cells: CD34+CD38– and CD117+ in bone marrow (BM) before and after applying either fresh or cryopreserved with various regimens placental cell suspension (PCS). PCS was cryopreserved with either 10% dimethyl sulfoxide or 10% propane diol saccharol. The maximum therapeutic effect was found after the introduction of fresh PCS (day 14) and suspension, cryopreserved with propane diol saccharol (day 28). The introduction of any from of PCS positively affected the erythrocyte sedimentation rate (ESR), CIC, nucleated cells in bone marrow, but the effect was manifested at different terms. The application of cryopreserved suspensions cont-ributed to the restoration of proliferative activity of hematopoietic stem cells. Depending on the cryopreservation regimen of the PCS, the properties of the injected suspension changed which affected the recovery time of the number of CD117+-cells.
Probl Cryobiol Cryomed 2019; 29(1): 028–043
References
Borysov P, Dimitrov A, Ostankov M, Goltsev A. The effect of cryopreservation on the expression of nanog, oct4, sox2 genes in hematopoietic and mesenchymal stem cells of murine fetal liver. In: CRYO 2015 Abstracts book of 52nd annual meeting of the society for cryobiology; 2015 July 26–29, Ostrava, Czech Republic. Ostrava; 2015. p. 44. CrossRef
Colmegna I, Weyand CM Haematopoietic stem and progenitor cells in rheumatoid arthritis. Rheumatology (Oxford). 2011; 50 (2): 252–60. CrossRef
Goltsev AN, Gayevskaya YuA, Dubrava TG, Ostankova LV. Effect of cryopreservation on functional status of bone marrow hematopoietic and mesenchymal stem cells in animals with autoimmune pathology. Probl Cryobiol Cryomed. 2016; 26(1): 63–72. CrossRef
Goltsev AN, Lutsenko ED, Ostankov MV, Bondarovich NA. [Estimation of cytokine profile in adjuvant arthritis model after cryopreserved placenta cells application]. Pathologia. 2011; 8(2): 99–101. Russian.
Goltsev AN, Lutsenko ED, Ostankov MV, Dimitrov AYu.Cryopreservation conditions determine the expression level of indolamine 2,3-dioxigenase gene in placental cells. In: Innovation of low temperature preservation and biobanking. Book of abstract SLTB 2013 meeting; 2013 Oct. 6-9 Hannover, Germany. Hannover; 2013. p.65.
Goltsev AN, Ostankova LV, Lutsenko ED, et al. Response of the lymphohemopoietic system of the organism on the in jection of the protectc of the fetoplacental complex. Problems of Cryobiology. 2000; (2): 15–30.
Goltsev AN, Ostankova LV, Lutsenko OD, et al., inventors. Institute for Problems of Cryobiology and Cryomedicine of NAS of Ukraine, assignee. [A method of comparative assessment of the effectiveness of treatment]. Ukraine patent 2004031694. 2004 Dec 15. Ukrainian.
Grishchenko VI, Morozova TF, Vorotilin OM, et al. [Preparation and storage of cryopreserved placental suspension for clinical use: methodical recommendations]. Kharkiv; 1997. 14 p. Ukrainian.
Grjibovsky AM. [Analysis of three and more independent groups of quantitative data]. Human Ecology. 2008; (3): 50–8. Russian.
Hao QL, Shah AJ, Thiemann FT, Smogorzewska EM, Crooks GM. A Functional Comparison of CD34+CD38- Cells in Cord Blood and Bone Marrow. Blood. 1995; 86 (10): 3745–53. PubMed
He J, Zhang Y, Jiang XX, et al. Isolation and characterization of human placenta derived adherent cells and their hematopoietic growth factor expression. Zhonghua Xue Ye Xue ZaZhi. 2003; 24 (2): 652–4. PubMed
Levshyts VM, Sydelnykova VM. [Medical laboratory tests. Directory]. Moscow: TRYADA.-Kh; 2000. 312 p. Russian.
Lutsenko ED. [Populational content and functional potential of placenta cells cryopreservated by various modes]. World ob Medicine and Biology. 2009; (3): 105–9. Russian.
Mahéva M, Audia S, De Lastours V, et al. Neutropenia in Felty’s syndrome successfully treated with hydroxychloroquine. Haematologica [Internet]. 2007 Jul 1 [cited 2017 Jul 1]; 92 e78. Available from: http://www.haematologica.org/content/92/7
Menshikov VV, Deletorskay IH, Zolotnitskay RP. Laboratory methods of research in clinic: the Directory. Ðœoscow: Medicine; 1987. 368 p. Russian.
Mischenko OY, Kotvitska AA. [Pharmacological efficacy of the analbic emulsion on the model of adjuvant arthritis in rats]. Visnyk farmatsii. 2001; (3): 124–5. Ukrainian.
Moiseyeva OM, Lyasnikova YeA, Semenova EG, et al.[Transforming factor-b1 and markers of leukocytic activation in hypertensive disease]. Arterial hypertensia. 2003; 9 (1): 14–6. Russian.
Ovchinnikova OV, Bondarenko IA, Lazurenko VV, et al. Application of cryopreserved cord blood in treatment of hypoferric anemia of pregnants. Problems of Cryobiology. 2008; 18 (3): 361–3.
Owlia MB, Newman K, Mojtaba Akhtari M. Felty’s Syndrome, Insights and Updates. Open Rheumatol J. 2014; (8): 129–36. CrossRef
Riether C, Schurch CM, Ochsenbein AF. Regulation of hematopoietic and leukemic stem cells by the immune system. Cell Death Differ. 2015; (22): 187–98. CrossRef
Rumyantsev PO, Saenko VA, Rumyantseva UV. [Statistical methods for the analyses in clinical practice. Part 1. Univariate statistical analysis]. Problems of Endocrinology. 2009; (5): 48–55. Russian.
Struchkov PV, Konstantynova NA, Lavrentev VV, Chuchalyn AH. [Screening test for the evaluation of pathogenic properties of circulating immune complexes]. Lab. delo. 1985; (7): 410–2. Russian. PubMed
Thorén LA, Liuba K, Bryder D, Nygren JM. Kit regulates maintenance of quiescent hematopoietic stem cells. J Immunol. 2008; 180 (4): 2045–53. CrossRef
Tsutsayeva AA. [Profound cold anabiosis and immunology]. Problems of Cryobiology. 1997; (1–2): 23–5.
Vatutin NT, Smirnova AS, Kalinkina NV, Shevelok AN. [Anemia in Patients with Rheumatoid Arthritis: features of pathogenesis, diagnostics and treatments]. Russian Medical Journal [Internet]. 2013 03 Sept [cited 10.01.2018]; (21): 1069. Available from: https://www.rmj.ru/articles/zabolevaniya_kostno_myshechnoy_sistemy/Anemiya_u_bolynyh_revmatoidnym_artritom_osobennosti_patogeneza_diagnostiki_i_lecheniya/ Russian.
Venezia TA, Merchant AA, Ramos CA, et al. Molecular signatures of proliferation and quiescence in hematopoietic stem cells. PLoS Biol [Internet]. 2004 Oct [cited 23.01.2019]; 2(10): e301. Available from: https://journals.plos.org/plosbiology/article?id=10.1371/journal.pbio.0020301
Downloads
Published
How to Cite
Issue
Section
License
Authors who publish with this journal agree to the following terms:
- Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.
- Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.
- Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).
