Experimental Cryoablation of Thyroid Gland with Propilthiouracyl-Induced Diffuse Hyperplasiae
DOI:
https://doi.org/10.15407/cryo31.02.168Keywords:
thyroid gland, cryoablation, propylthiouracil, diffuse hyperplasia, ratsAbstract
Cryoablation under endoscopic control is considered to be a promising approach in therapy of benign nodules of thyroid gland (TG). However, pathologically altered TG tissue differs in thermal conductivity and heat capacity from normal one, therefore the model experiments in animals are necessary to determine the cryoablation parameters. In this research, the changes of temperature during cryoablation of experimental rat TG under normal conditions and the one with propylthiouracil (PTU)-induced diffuse hyperplasia (DH) were comparatively assessed. TG was cryo-ablated in rats, previously received a 0.1% PTU solution within 90 days, using a copper cryoprobe, cooled to liquid nitrogen temperature. The process was controlled using thermocouples placed at different distances from the iceball. Differences between thermograms of intact TG tissue and the samples with PTU-induced DH were established. To achieve the destruction effect of TG with DH to a depth of more than 1 mm, the need of implementing two freeze-thaw cycles with 120-second cryoprobe exposure was proven.
Probl Cryobiol Cryomed 2021; 31(2): 168–179
References
Balabolkin MI, Klebanova EM, Kreminskaya BM. [Fundamental and clinical thyroidology: a guide]. Moscow: Medicine, 2007. 816 p. Russian.
Bergenfelz A, Jansson S, Kristoffersson A, et al. Complications to thyroid surgery: results as reported in a database from a multicenter audit comprising 3,660 patients. Langenbecks Arch Surg 2008; 393 (5): 667-73. CrossRef
Borkowski M., Robinson MJ, Poppiti RJ, et al. Histologic findings in postcryosurgical prostatic biopsies. Mod Pathol. 1996; 9 (8): 807-11.
Butova OA, Botasheva VS, Golovko EM. [Pathological characteristics of the thyroid gland with endemic goiter]. Stavropol State University's Vestnik. 2010; (69):182-6. Russian.
Chizh NA. Endoscopic Cryosurgery. Probl Cryobiol Cryomed. 2017; 27(1): 3-18. CrossRef
Erinjeri JP, Clark TW. Cryoablation: mechanism of action and devices. J Vasc Interv Radiol. 2010; 21 (8, Suppl): S187-S191. CrossRef
Gage AA, Baust JG. Cryosurgery - a review of recent advances and current issues. Cryo Letters. 2002; 23(2): 69-78. PubMed
Gage AA, Baust J. Mechanisms of tissue injury in cryosurgery. Cryobiology. 1998; 37 (3): 171-86. CrossRef
Garberoglio R, Aliberti C, Appetecchia M, et al. Radiofrequency ablation for thyroid nodules: which indications? The first Italian opinion statement. J Ultrasound. 2015;18 (4): 423-30. CrossRef
Hamed MS, Mansour SZ, Halawa MR, et al. Cryoablation of goiter irrespective of thyroid profile. Thyroid Res Pract. 2019; 16 (1): 6-11. CrossRef
Khaziyev VV, Tjazhelova OV, Makedonskaya VA. Sonographic changes in structure and volume of thyroid gland after local intrasurgical cryoexposure in patients with nodular euthyroid goiter. Probl Cryobiol Cryomed. 2013; 23 (3): 240-6. Full Text
Kim C, O'Rourke AP, Mahvi DM, et al. Finite-element analysis of ex vivo and in vivo hepatic cryoablation. IEEE Trans Biomed Eng. 2007; 54(7): 1177-85. CrossRef
Korzhevskij DE, Gilyarov AV. [Fundamentals of histological technique]. St Petersburg: SpecLit,, 2015. 807 p. Russian.
Laezza C, Mazziotti G, Fiorentino L, et al. HMG-CoA reductase inhibitors inhibit rat propylthiouracil-induced goiter by modulating the ras-MAPK pathway. Mol Med (Berl). 2006; 84 (11): 967-73. CrossRef
Morelli F, Sacrini A, Pompili G, et al. Microwave ablation for thyroid nodules: a new string to the bow for percutaneous treatments? Gland Surg. 2016; 5(6): 553-8. CrossRef
Pobelensky KO, Kolot NV, Protsenko ES, et al. [Dynamics of morphological parameters of the thyroid gland in hypertensive SHR rats upon administration of propylthiouracil]. Morphologia. 2019; 13 (3): 93-8. Ukrainian. CrossRef
Polychronakos C, Guyda HJ, Patel B, et al. Increase in the number of type II insulin-like growth factor receptors during propylthiouracil-induced hyperplasia in the rat thyroid. Endocrinology. 1986; 119 (3): 1204-9. CrossRef
Pomorski L, Bartos M, Amsolik M, et al. Thyroid cryotherapy in an experimental rat model-topography of temperature during therapy and functional results. Cryobiology. 2000; 41 (1): 51-7. CrossRef
Pomorski L, Bartos M, Matejkowska M, et al. Thyroid cryotherapy in an experimental rat model. Cryobiology. 1999; 39 (3): 262-70. CrossRef
Rognoni JB, Penel C, Bastiani P, et al. Involution of hyperplastic goitre in the adult male rat. Tissue compartment process with early iodide effect: a stereological and biochemical study. Arch B Cell Pathol Incl Mol Pathol. 1987; 53 (3): 166-75. CrossRef
Sabel MS. Cryo-immunology: A review of the literature and proposed mechanisms for stimulatory versus suppressive immune responses. Cryobiology. 2009; 58 (1): 1-11. CrossRef
Tegler L, Gillquist J, Anderberg B, Lundström B, Johansson H. Thyroid blood flow rate in man. Electromagnetic flowmetry during operation in euthyroid normal gland, nontoxic goiter, and hyperthyroidism. J Endocrinol Invest. 1981; 4(3): 335-41. CrossRef
Valcavi R, Frasoldati A. Ultrasound-guided percutaneous ethanol injection therapy in thyroid cystic nodules. Endocr Pract. 2004; 10 (3): 269-75. CrossRef
Valcavi R, Riganti F, Bertani A, et al. Percutaneous laser ablation of cold benign thyroid nodules: a 3-year follow-up study in 122 patients. Thyroid. 2010; 20 (11):1253-61. CrossRef
Vita R, Di Bari F, Perelli S, et al. Thyroid vascularization is an important ultrasonographic parameter in untreated Graves' disease patients. J Clin Transl Endocrinol. 2019;15: 65- 9. CrossRef
Zhang YT, Liu J, Zhou YX. Pilot study on cryogenic heat transfer in biological tissues embedded with large blood vessels. Forschung Im Ingenieurwesen. 2002; 67(5): 188-97. CrossRef
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