Placental Cryoextract and Renin-Angiotensin-Aldosterone System Blockade Mitigate Renal Failure in Rats
DOI:
https://doi.org/10.15407/cryo31.03.223Keywords:
chronic renal failure, placental cryoextract, drug blockade of renin-angiotensin-aldosterone system, morphology, creatinineAbstract
Here, we have studied the impact of administration of rat placental cryoextract (PCE), drug blockade of the renin-angiotensin-aldosterone system (RAAS) with enalapril and spironolactone and their combination on the rat kidney tissue structure and excretory function at different stages of chronic renal failure (CRF) development using the glycerol model. In 3 weeks after glycerol introduction, the animals from all the groups showed low values of glomerular filtration rate, impaired blood flow in renal cortex, tubular epithelial dystrophy, inflammation and edema of interstitium, indicating the onset of CRF development. Tubulo-interstitial nephritis and nephrosclerosis were dominated in untreated rats 16 weeks later. The use of RAAS drug blockade, as well as a comprehensive therapy with RAAS blockers and placental cryoextract stopped the inflammatory processes in renal tissue, restored blood circulation and normalized excretory function, which persisted for up to 16 weeks of observation.
Probl Cryobiol Cryomed 2021; 31(3): 223–235
References
Dai C, Kiss LP, Liu Y. Animal models of kidney diseases. In: Conn PM, editor. Sourcebook of models for biomedical research. Totowa: Humana Press; 2008. p. 657-64.
Danilova LA. [Analyzes of human blood, urine and other biological fluids at different age periods.] 3rd ed. St. Petersburg: SpetsLit; 2019. 119 p. ISBN 978-5-299-01019-0 Russian.
Fira LS, Nikolayev VG, Klisch IN, et al. [Study of efficiency of enterosgel at experimental renal failure]. Emergency Medicine. 2011;(1-2):91-4. Russian.
Gryschenko VI, Yurchenko TN. [Placenta: cryopreservation, structure, properties, perspectives of clinical use]. Kharkiv: Brovin AV, 2011. 292 p. Russian.
Iwatani H, Imai E. Kidney repair using stem cells: myth or reality as a therapeutic option? J Nephrol. 2010; 23(2): 143-6.
Kaplunova O.A. [Juxtaglomelular blood flow pathway in the kidney (comparative-anatomical and age-related aspects)]. Morphologiia. 2015;147(1): 53-8. Russian.
Keidar S, Kaplan M, Pavlotzky E, et al. Aldosterone administration to mice stimulates macrophage NADPH oxidase and increases atherosclerosis development: a possible role for angiotensin-converting enzyme and the receptors for angiotensin II and aldosterone. Circulation. 2004; 109(18): 2213-20.
Kirpatovskiy VI, Kazachenko AV, Kon'kova TA, et al. Functional after effects of intraparenchymatous injection of human fetal stem and progenitor cells to rats with chronic and acute renal failure. Bull Exp Biol Med. 2006; 141(4): 500-6.
Kirpatovskiy VI, Kazachenko AV, Plotnikov EYu, et al. [Experimental evaluation of novel technologies for acute renal failure preventing and treatment]. Experimental & Clinical Urology. 2010; (1): 30-6. Russian.
Kutyrina, IM, Lifshits, NL, Rogov VA, et al. [Administration of angiotensin-converting enzyme inhibitor synchronic renal failure]. Terapevticheskii Arkhiv. 2002; 74 (6): 34-9. Russian.
Li K, Chen Yu, Zhang J, et al. Microenvironment derived from metanephros transplantation inhibits the progression of acute kidney injury in glycerol-induced rat models. Renal Failure. 2020; 42(1): 89-97.
Luno J, Barrio V, Goicoechea MA et al. Effect of dual blockade of the renin-angiotensin system in primary proteinuric nephropathies. Kidney Int. 2002; 62(Suppl.82): S47-S52.
Marisa KA, Clarke EA, Bertram P. The renin-angiotensinaldosterone system and its suppression. J Vet Intern Med. 2019;33(2):363-82.
Moiseev SV, Arutyunov GP, Fomin VV. [ACE inhibitors and nephroprotection in chronic proteinuric nephropathies]. Clinical Nephrology. 2009; 2: 31-6. Russian.
Nagase M, Shibata S, Yoshida S, et al. Podocyte injury underlies the glomerulopathy of Dahl salt-hypertensive rats and is reversed by aldosterone blocker. Hypertension. 2006; (47): 1084-93.
Nikolaev KYu, Nikolaeva AA, Popova LV, et al. [Pathogenesis of chronic renal failure in patients with hypertension (review)]. Kazan Medical Journal. 2015; 96 (4): 659-65. Russian.
Osikov MV, Gizinger OA, Cherepanov DA. [Pathogenesis of immune alterations and corrective role of amlodipine in experimental chronic renal failure]. Meditsinskaya Immunologiya. 2016; 18(3): 231-2. Russian.
Repin NV, Marchenko LN, Govorukha TP, et al. [Ultrastructure of rat adrenal glands with chronic renal insufficiency following placental cryoextract therapy in the course of RAAS medicated blocking]. Ukrainian Journal of Medicine, Biology and Sport. 2019;4(6): 349-55. Ukrainian.
Repin NV, Chizh YuA, Marchenko LN, Govorukha TP. [Morphological characteristics of aortal endothelium in rats with renal insufficiency following correction by allogenic placental cryoextract]. Ukrainian Journal of Medicine, Biology and Sport. 2020; 5(4): 379-85. Russian.
Romanenko AM, Nepomnyashchyi VM [Morphological diagnosis of nephrological diseases]. In: [Nephrology]. Kyiv: Zdorov'ya; 2004. p. 38-97. Russian.
Rybolovlev YuR, Rybolovlev RC. [Dosing of substances for mammals by biological activity constants]. Reports of Academy of Sciences of the USSR. 1979; 247(6): 1513-6. Russian.
Sharfuddin AA, Molitoris BA. Pathophysiology of ischemic acute kidney injury. Nat Rev Nephrol. 2011; (7): 189-200.
Shibata S, Nagase M, Yoshida S, et al. Podocyte as the target for aldosterone: roles of oxidative stress and Sgk1. Hypertension. 2007; (49): 355-64.
Snyder S, Pendergraph B. Detection and evaluation of chronic kidney disease. Am Fam Physician. 2005; 72(9): 1723-32.
Sunil KG, Mehran A, Tae-Hyoung K, et al. Effect of human amniotic fluid stem cells on kidney function in a model of chronic kidney disease. Tissue Eng Part A. 2019; 25(21-22): 1493-503.
Tareyeva IE. [Nephrology: a guide for physicians]. Moscow: Meditsina; 2000.687 p. Russian.
Yurchenko TN, Kondakov II, Strona VI. Renal effects following introduction of cryopreserved placental extract on the background of experimental renal failure. Probl Cryobiol Cryomed. 2014; 24(1): 75-8
Downloads
Published
How to Cite
Issue
Section
License
This work is licensed under a Creative Commons Attribution 4.0 International License.
Authors who publish with this journal agree to the following terms:
- Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.
- Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.
- Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).
