Brain Cortex Morphology in Rats After Cold Exposures
DOI:
https://doi.org/10.15407/cryo33.03.193Keywords:
cold, brain cortex morphology, fractal dimension, short-term intermittent cold exposures, long-term continuous cold exposureAbstract
Morphological changes of the brain cortex sensorimotor area in 6-month-old rats were studied after short-term intermittent and long-term continuous cold exposures (STICE and LTCCE, respectively). Under these conditions, perivascular and pericellular edema, small solitary foci of necrosis with gliosis phenomena, "porous" neuropil (signs under STICE at –12°С and formation during LTCCE), dystrophically changed neurons, neurons with nuclei at different stages of necrobiosis were noted in the brain tissue against the background of native cyto- and myeloarchitectonics, Some of the microvessels had signs of inflammation and thrombi. A moderate constriction (after STICE at –12°С) and a dilatation (after STICE at 10°С) of microvessels were observed. According to the fractal analysis, a decrease in the fractal dimension of the brain cortex sections was found under both STICE at –12°С and LTCCE.
Probl Cryobiol Cryomed 2023; 33(3):193–200
References
Bai J, Lyden PD. Revisiting cerebral postischemic reperfusion injury: new insights in understanding reperfusion failure, hemorrhage, and edema. Int J Stroke. 2015; 10(2): 143-52.
Bradl M, Lassmann H. Oligodendrocytes: biology and pathology. Acta Neuropathol. 2010; 119(1): 37-53.
Coimbra-Costa D, Alva N, Duran M, et al. Oxidative stress and apoptosis after acute respiratory hypoxia and reoxygenation in rat brain. Redox Biol. 2017; 12: 216-25.
Elshama SS, Osman H-EH, El-Kenawy AEl-M. Postmortem diagnosis of induced fatal hypothermia in adult albino rats. Rom J Leg Med. 2016; 24(2): 106-14.
Garman RH. Histology of the central nervous system. Toxicol Pathol. 2011; 39(5): 22-35.
Ito U, Hakamata Y, Kawakami E, Oyanagi K. Degeneration of astrocytic processes and their mitochondria in cerebral cortical regions peripheral to the cortical infarction: heterogeneity of their disintegration is closely associated with disseminated selective neuronal necrosis and maturation of injury. Stroke. 2009; 40(6): 2173-81.
Kitchen P, Salman MM, Halsey AM, et. al. Targeting Aquaporin-4 Subcellular Localization to Treat Central Nervous System Edema. Cell. 2020; 181(4): 784-799.e19. doi: 10.1016/j.cell.2020.03.037.
Kryzhanovsky GN. [General pathophysiology of the nervous system: A guide.] Moscow: Medicina; 1997: 351 p. Russian
Kvitnitsky-Ryzhov YuN. [Edema and swelling of the brain]. Kyiv: Zdorov'ya; 1978: 184 p. Russian
Launay J-C, Savourey G. Cold adaptations. Ind Health. 2009; 47(3): 221-27.
Liu J, Wang A, Li L, et al. Oxidative stress mediates hippocampal neuron death in rats after lithium-pilocarpine-induced status epilepticus. Seizure. 2010; 19(3): 165-72.
Lutsenko DG, Marchenko VS, Babiychuk VG. NO-Dependent mechanisms of rhythmic cold exposures on functional architectonics of microhemocirculatory bed in rat brain. Problems of Cryobiology. 2011; 21(2): 117-24.
Mäkinen TM, Mäntysaari M, Pääkkönen T, et al. Autonomic nervous function during whole-body cold exposure before and after cold acclimation. Aviat Space Environ Med. 2008; 79(9): 875-82.
Mandelbrot BB. Fractals - form, chance and dimension. San-Francisco: W.H. Freeman; 1977. 365 p.
Maryenko NI, Stepanenko OYu. [Fractal analysis of human cerebellum based on magnetic resonance imaging data: pixel dilating method]. Morphologia. 2020; 14(3): 52-8. Ukrainian.
Marzi C, Giannelli M, Tessa C, et al. Toward a more reliable characterization of fractal properties of the cerebral cortex of healthy subjects during the lifespan. Sci Rep. 2020 Oct 12 [cited 2022 Nov 20];10(1): 16957. Available from: https://www.nature.com/articles/s41598-020-73961-w doi: 10.1038/s41598-020-73961-w.
Meregalli V, Alberti F, Madan CR, et al. Cortical complexity estimation using fractal dimension: A systematic review of the literature on clinical and nonclinical samples. Eur J Neurosci. 2022; 55(6): 1547-83.
Nicholls JG, Martin AR, Fuchs PA, et al. From neuron to brain. 5th ed. Sunderland: Sinauer Associates; 2012. 768 p.
Pekny M, Pekna M. Astrocyte reactivity and reactive astrogliosis: costs and benefits. Physiol Rev. 2014; 94(4): 1077-98.
Schindelin J, Arganda-Carreras I, Frise E, et al. Fiji: an open-source platform for biological-image analysis. Nat Methods. 2012; 9: 676-82.
Tansey EA, Johnson CD. Recent advances in thermoregulation (Review). Adv Physiol Education. 2015; 39(3): 139-48.
Tumansky VA, Evseev AV, Polkovnikov YuF. Apoptosis and selective necrosis of CNS neurons after clinical death and cerebral ischemia: molecular mechanisms and morphological features. Pathologia. 2008; 5(2): 19-28. Russian
Wang H, Wang B, Normoyle KP, et al. Brain temperature and its fundamental properties: a review for clinical neuroscientists. Front Neurosci [Internet]. 2014 Oct 08 [cited 2022 Nov 20]; 8: 307. Available from: https://www.frontiersin.org/articles/10.3389/fnins.2014.00307/full
Wang X, Michaelis EK. Selective neuronal vulnerability to oxidative stress in the brain. Front Aging Neurosci. 2010 Mar 30 [cited 2022 Nov 20]; 2: 12. Available from: https://www.frontiersin.org/articles/10.3389/fnagi.2010.00012/full
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