Therapy with Fetal Neuronal Cells in Acute Period of Experimental Ischemic Stroke (Antioxidative Effect)

Authors

  • D. V. Lebedinets Institute for Problems of Cryobiology and Cryomedicine of the National Academy of Sciences of Ukraine, Kharkov
  • S. Ye. Ovsyannikov Institute for Problems of Cryobiology and Cryomedicine of the National Academy of Sciences of Ukraine, Kharkov
  • V. V. Lebedinets Central Clinical Hospital of Ukrainian Railways, Kharkov
  • M. V. Ostankov Institute for Problems of Cryobiology and Cryomedicine of the National Academy of Sciences of Ukraine, Kharkov
  • A. N. Goltsev Institute for Problems of Cryobiology and Cryomedicine of the National Academy of Sciences of Ukraine, Kharkov

Keywords:

cryopreserved fetal neuronal cells, lipid peroxidation, brain ischemia

Abstract

In this research there are presented the results of the effect of cryopreserved fetal neuronal cells (cFNCs) on the dynamics of neurological deficit and state of the processes of lipid peroxidation (LPO) in an acute period of brain ischemia in white rats. It has been shown that the introduction of cFNCs corrected the impairment of LPO activity, reduced the level of free radical metabolites in brain substance, liver and blood serum, strengthened endogenous antioxidant protection, improved clinical status of rats and increased the viability index of the animals. The carried-out studies revealed statistically significant effect of introduced intraperitoneally cFNCs in an acute period of experimental brain ischemia of laboratory animals. The findings enable the considering of the application of cFNCs in a combined treatment of ischemic impairments of brain blood circulation as perspective one.

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Published

2010-09-20

How to Cite

Lebedinets, D. V., Ovsyannikov, S. Y., Lebedinets, V. V., Ostankov, M. V., & Goltsev, A. N. (2010). Therapy with Fetal Neuronal Cells in Acute Period of Experimental Ischemic Stroke (Antioxidative Effect). Problems of Cryobiology and Cryomedicine, 20(3), 338–347. Retrieved from https://journal.cryo.org.ua/index.php/probl-cryobiol-cryomed/article/view/194

Issue

Vol. 20 No. 3 (2010): Problems of Cryobiology

Section

Cryomedicine, Clinical and Experimental Transplantology

License

Copyright (c) 2020 D. V. Lebedinets, S. Ye. Ovsyannikov, V. V. Lebedinets, M. V. Ostankov, A. N. Goltsev

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