State of Vegetative and Humoral Regulations of Cardiac Rhythm in Young and Aged Rats on Background of Rhythmic Extreme Cooling (–120°C) Combined with Application of Cord Blood Nucleated Cells

Authors

  • Yuliya V. Rudneva Institute for Problems of Cryobiology and Cryomedicine of the National Academy of Sciences of Ukraine, Kharkov
  • Vladislav G. Babiychuk Institute for Problems of Cryobiology and Cryomedicine of the National Academy of Sciences of Ukraine, Kharkov
  • Elena A. Chernyavskaya Institute for Problems of Cryobiology and Cryomedicine of the National Academy of Sciences of Ukraine, Kharkov
  • Vladimir V. Kulik Institute for Problems of Cryobiology and Cryomedicine of the National Academy of Sciences of Ukraine, Kharkov

Keywords:

rhythmic extreme cold exposures, cord blood nucleated cells, heart rate variability, neurohumoral regulation, cryochamber

Abstract

Spectral analysis of heart rate variability was used to study the state of vegetative and humoral regulations of heart rate in young and aged rats after combined use of rhythmic extreme cold exposures (RECE) and introduction of cord blood nucleated cells (CBNC). Thre was shown a positive effect of RECE and CBNC introduction on functional state of regulatory systems in organism of the animals regardless of age; that was confirmed by the rise of indices of total power spectrum of neurohumoral regulation due to activation of vegetative nervous system and humoral link of regulation. The findings testified that the process of heart rate control in aged animals after RECE and CBNC administration transited from a slow humoral-metabolic regulation level to a rapid vegetative level, not intrinsic to an aged organism. Probl Cryobiol Cryomed 2013; 23(4):318–325.

Author Biographies

Yuliya V. Rudneva, Institute for Problems of Cryobiology and Cryomedicine of the National Academy of Sciences of Ukraine, Kharkov

Department of Cryophysiology

Vladislav G. Babiychuk, Institute for Problems of Cryobiology and Cryomedicine of the National Academy of Sciences of Ukraine, Kharkov

Department of Cryophysiology

Elena A. Chernyavskaya, Institute for Problems of Cryobiology and Cryomedicine of the National Academy of Sciences of Ukraine, Kharkov

Department of Cryophysiology

Vladimir V. Kulik, Institute for Problems of Cryobiology and Cryomedicine of the National Academy of Sciences of Ukraine, Kharkov

Department of Cryophysiology

References

Aydaraliyev A.A., Maksimov A.L. Human adaptability to extreme conditions. Leningrad: Nauka, 1988.

Babiychuk V.G. Comparative characteristics of cardiac rhythm in rats using different methods of cold exposures. Problems of Cryobiology 2007; 17 (3): 229–236.

Baevsky R.M., Berseneva A.P. Estimation of adaptable opportunities of an organism and risk of diseases development. – Moscow, 1997.

Butenko G.M., Voytenko V.P. Genetic and immunologic mechanisms of age pathology. – Kyiv: Zdorov'ya, 1983.

Voronin I.M., Govsha Yu.A., Istomina T.A., Belov A.M. Variability and spectral analysis of cardiac rhythm in diagnosis of dysfunction of the sinus node. Kardiologiia 1999; (10): 32–34.

Korkushko O.V. Cardiovascular system and age – Moscow: Meditsina, 1983.

Kryzhanovsky G.N. General pathophysiology of nervous system: Handbook. Moscow: Meditsina, 1997.

Matusova A.P. Clinical value of statistical analysis of cardiac rhythm in patients with acute myocardial infarction. Kardiologiya 1989; 29 (1): 29–32.

Smetnev A.S., Zharinov O.I., Chubuchny V.N. Heart rate variability, ventricular arrhythmias and risk of sudden death. Kardiologiia 1995; 34 (4): 49–52.

Frolkis V.V. Syndromes of aging. Vestnik AMN SSSR 1990; (1): 8–13.

Frolkis V.V. Brain aging. – Leningrad: Nauka, 1991.

Shiman A.G., Kiryanova V.V., Maksimova A.V. et al. Clinical and physiological aspects of cryotherapy. Vestnik of North–Western State Medical Academy named after I.I. Mechnikov 2001; (1): 27–34.

Patent N 40168 Ukraine, IPC A61V 18/00. Cryochamber for experimental cooling of laboratory animals / G.O. Babiychuk, O.V. Kozlov, I.I. Lomakin, V.G. Babiychuk; owned by the Institute for Problems of Cryobiology and Cryomedicine of the National Academy of Sciences of Ukraine. – Appl. u200812930 06.11.1998; Publ. 25.03.2009. – Bull. Nr. 6.

Patent N92227 Ukraine IPC Ð01N1/02. Method of cryopreservation of nucleated cells of cord blood including hemopoietic stem cells / L.O. Babiychuk, V.I. Grischenko, T.M. Gurina et al.; Appl. â„–200814009 05.12.2008: Publ.11.10.2010. – Bul. Nr. 19.

Cornetta K., Laughlin M., Carter S. Umbilical cord blood transplantation in adults: results of the prospective Cord Blood Transplantation (COBLT). Biol Blood Marrow Transplant 1995; 2 (11): 149–160.

Gluckman E., Broxmeyer H.A., Auerbach A.D. Hematopoietic reconstitution in a patient with Franconi’s anemia by means of umbilical-cord blood from an HLA-identical sibling. N Engl J Med 1989; 32 (17): 1174–1178.

Long G.D., Laughlin M., Madan B. Unrelated umbilical cord blood transplantation in adult patients. Biol Blood Marrow Transplant 2003; 9(12): 772–780.

Roccanova L., Ramphal P. The role of stem cells in the evolution of longevity and its application to tissue therapy. Tissue Cell 2003; 35(1): 79–81.

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Published

2013-12-30

How to Cite

Rudneva, Y. V., Babiychuk, V. G., Chernyavskaya, E. A., & Kulik, V. V. (2013). State of Vegetative and Humoral Regulations of Cardiac Rhythm in Young and Aged Rats on Background of Rhythmic Extreme Cooling (–120°C) Combined with Application of Cord Blood Nucleated Cells. Problems of Cryobiology and Cryomedicine, 23(4), 318–325. Retrieved from https://journal.cryo.org.ua/index.php/probl-cryobiol-cryomed/article/view/317

Issue

Vol. 23 No. 4 (2013): Problems of Cryobiology and Cryomedicine (Problemy Kriobiologii i Kriomediciny) (formerly Problems of Cryobiology)

Section

Cryomedicine, Clinical and Experimental Transplantology

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Copyright (c) 2020 Yuliya V. Rudneva, Vladislav G. Babiychuk, Elena A. Chernyavskaya, Vladimir V. Kulik

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