Applications of Cord Blood Cells in Neurology
DOI:
https://doi.org/10.15407/cryo26.02.103Keywords:
cell therapy, cord blood, stem cells, neurological deficitAbstract
This review represents the findings, reflecting the main achievements in the scope of cell based therapy of nervous diseases and therapeutic potential of cord blood cells in experimental and clinical neurology. The cord blood-derived cell populations are classified and the possibility of their application in therapy of neurological deficit is demonstrated. Different approaches to cord blood cell transplantation are considered, depending on administration way and cell concentration. Possible mechanisms of therapeutic effect of these cells, as well as their ability to migrate into the brain through the blood-brain barrier are discussed.
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Probl Cryobiol Cryomed 2016; 26(2):103-115.
References
Aoki M., Yasutake M., Murohara T. Derivation of functional endothelial progenitor cells from human umbilical cord blood mononuclear cells isolated by a novel cell filtration device. Stem Cells 2004; 22(6): 994–1002. CrossRef PubMed
Babijchuk L.A., Zubov P.M., Ryazantsev V.V. et al. Cord blood as an alternative source of stem cells for regenerative medicine: new approaches to cryopreservation. Bukovinian Medical Herald Journal 2009; 13(4): 23–26.
Babijchuk L.A., Kudokotseva O.V., Ryazantsev V.V. New perspectives in cryopreservation of cord blood nucleated cells. Hematology and Blood Transfusion; 2008 (34): 17–21.
Babijchuk L.O., Grischenko V.I., Gurina T.M. et al. at., inventors. Way for cryopreservation of cord blood nucleated cells, including hemopoietic stem cells. Patent of Ukraine N92227. 2010 Oct 11.
Babijchuk L.V., Babijchuk V.G., Sirotenko L.A. et al. Effect of cryopreserved umbilical cord blood nucleated cells on homeostasis state in animals of different age groups in stress-induced arterial hypertension. Genes and Cells 2014; 9(4): 88–94.
Bachstetter A.D., Pabon M.M., Cole M.J. et al. Peripheral injection of human umbilical cord blood stimulates neurogenesis in the aged rat brain. BMC Neuroscience 2008; 9 (Suppl. 1): 22. CrossRef PubMed
Barker R.A., Beaufort I. Scientific and ethical issues related to stem cell research and interventions in neurodegenerative disorders of the brain. Prog Neurobiol 2013; 110(1): 63–73. CrossRef PubMed
Belous A.M., Grischenko V.I. Cryobiology. Kiev: Naukova Dumka; 1993.
Bersenev A.V. Cell transplantation: history, current state and prospects. Cellular Transplantation and Tissue Engineering 2005; 1(1): 49–56.
Bicknese A.R., Goodwin H.S., Quinn C.O. et al. Human umbilical cord blood cells can be induced to express markers for neurons and glia. Cell Transplant 2002; 11(3): 261–264. PubMed
Borlongan C.V., Hadman M., Sanberg C.D., Sanberg P.R. Central nervous system entry of peripherally injected umbilical cord blood cells is not required for neuroprotection in stroke. Stroke 2004; 35: 2385–2389. CrossRef PubMed
Buzanska L., Machaj E.K., Zablocka B. et al. Human cord blood-derived cells attain neuronal and glial features in vitro. J Cell Sci 2002; 115 (Pt. 10): 2131–2138. PubMed
Chang C.K., Chang C.P., Chiu W.T., Lin M.T. Prevention and repair of circulatory shock and cerebral ischemia/injury by various agents in experimental heatstroke. Current Medicinal Chemistry 2006; 26(13): 3145–3154. CrossRef
Chen R., Ende N. The potential for the use of mononuclear cells from human umbilical cord blood in the treatment of amyotrophic lateral sclerosis in SOD1 mice. J Med 2000; (31): P. 21–30. PubMed
Chen J., Sanberg P.R., Li Y. et al. Intravenous administration of human umbilical cord blood reduces behavioral deficits after stroke in rats. Stroke 2001; 32(11): 2682–2688. CrossRef PubMed
Chernyavskaya E.A. Features of autonomic and humoral regulation of heart rate in rats with alimentary obesity at the background of cord blood administration. Heart rate variability: theoretical and applied aspects. Proceedings of the All-Russian Scientific and Practical Conference with International Parti-cipation. Cheboksary: Chuvash State Pedagogical University; 2014: 169–174.
Compagnucci C., Nizzardo M., Corti S. et al. In vitro neuoge-nesis: development and functional implications of iPSC technology. Cell Mol Life Sci 2014; 71(9): 1623–1639. CrossRef PubMed
Cramer A.O., MacLaren R.E. Translating induced pluripotent stem cells from bench to bedside: application to retinal diseases. Curr Gene Ther 2013; 13(2): 139–151. CrossRef
Ende N., Weinstein F., Chen R., Ende M. Human umbilical cord blood effect on sod mice (amyotrophic lateral sclerosis). Life Sciences 2000; (67): 53–59. CrossRef
Erices A., Conget P., Minguell J.J. Mesenchymal progenitor cells in human umbilical cord blood. Br J Haematol 2000; 109(1): 235–242. CrossRef PubMed
Fan C.G., Zhang Q.J., Tang F.W. et al. Human umbilical cord blood cells express neurotrophic factors. Neurosci Lett 2005; 380: 322–325. CrossRef PubMed
Fu Y.S., Shih Y.T., Cheng Y.C., Min M.Y. Transformation of human umbilical mesenchymal cells into neurons in vitro. J Biomed Sci 2004; (11): 652–660. CrossRef PubMed
Gallacher L., Murdoch B., Wu D.M. et al. Isolation and characterization of human CD34(–)Lin(–) and CD34(+)Lin(–) hematopoietic stem cells using cell surface markers AC133 and CD7. Blood 2000; 95: 2813–2820. PubMed
Garbuzova-Davis S., Willing A.E., Zigova T. et al. Intravenous administration of human umbilical cord blood cells in a mouse model of amyotrophic lateral sclerosis: distribution, migration, and differentiation. J Hematother Stem Cell Res 2003; 12(3): 255–270. CrossRef PubMed
Goltsev A.N., Kalinichenko T.A. Human umbilical cord blood as a source of hemopoietic cells for clinical application. Part 1. Nature of hemopoietic potential. Problems of Cryobiology 1998; (1): 3–24.
Goodwin H., Bicknese A., Chien S. et al. Multilineage differentiation activity by cells isolated from umbilical cord blood: expression of bone, fat, and neural markers. Biol Blood Marrow Transplant 2001; 7(11): 581–588. CrossRef PubMed
Greenberg D.A., Jin K. Vascular endothelial growth factors (VEGFs) and stroke. Cell Mol Life Sci 2013; 70(10): 1753–1761. CrossRef PubMed
Grischenko V.I., Goltsev A.N. Transplantation of the products of embryofetoplacental complex. From understanding of mechanism of the effect to increasing the efficiency of application. Problems of Cryobiology 2002; (1): 54–84.
Grischenko V.I., Sandomirsky B.P. Concept of cell therapy. Problems of Cryobiology 2000; (1): 3–6.
Isayev A.A., Melikhova V.S. Cord blood cell application in clinical practice. Cellular Transplantology and Tissue Engineering 2008; 3(1): 34–43.
Jang Y.K., Park J.J., Lee M.C. et al. Retinoic acid-mediated induction of neurons and glial cells from human umbilical cord–derived hematopoietic stem cells. J Neurosci Res 2004; 75(4): 573–584. CrossRef PubMed
Jeong J.A., Gang E.J., Hong S.H. et al. Rapid neural differentiation of human cord blood–derived mesenchymal stem cells. Neuroreport 2004; 15(11): 731–1734. CrossRef
Kang K.-S., Kim S.W., Oh Y.H. et al. A 37-year-old spinal cord-injured female patient, transplanted of multipotent stem cells from human UC blood, with improved sensory perception and mobility, both functionally and morphologically: a case study. Cytotherapy 2005; (7): 368–373. CrossRef PubMed
Kern S., Eichler H, Stoeve J. et al. Comparative analysis of mesenchymal stem cells from bone marrow, umbilical cord blood, or adipose tissue. Stem Cells 2006; 24(5): 1294–1301. CrossRef PubMed
Kopen G.C., Prockop D.J., Phinney D.G. Marrow stromal cells migrate throughout forebrain and cerebellum, and they differentiate into astrocytes after injection into neonatal mouse brains. Proc Natl Acad Sci USA 1999; (96): 10711–10716. CrossRef PubMed
Kudokotseva O.V., Lomakin I.I., Babijchuk G.A. Cryopreserved cord blood products mitigate fluorouracil myelodepression in mice. Problems of Cryobiology and Cryomedicine 2015; 25(4): 359–370. CrossRef
Lebedinets V.V., Ovsyannikov S.E., Ostankov M.V. et al. Correction of metabolic disorders by introduction of cryopreserved cord blood in experimental model of ischemic stroke. Belgorod State University Scientific Bulletin: Medicine Pharmacy 2015; 31(16): 156–162.
Lee O.K., Kuo T. K., Chenet W.-M. et al. Isolation of multipotent mesenchymal stem cells from umbilical cord blood. Blood 2004; 103(5): 1669–1675. CrossRef PubMed
Lindvall O., Backlund E.O., Farde L. et al. Transplantation in Parkinson,s disease: two cases of adrenal medullary grafts to the putamen. Ann Neeurol 1987; (22): 457–463.
Lu D., Sanberg P.R., Mahmood A. et al. Intravenous administration of human umbilical cord blood reduces neurological deficit in the rat after traumatic brain injury. Cell Transplant 2002; (11): 275–281. PubMed
Lu C.Z., Xiao B.G. G-CSF and neuroprotection: a therapeutic perspective in cerebral ischaemia. Biochem Soc Trans 2006; 34(6): 1327–1333. CrossRef PubMed
Martynova Yu.V., Babijchuk L.V. Evaluation of neurohumoral regulation of heart rate in rat aging dynamics at the background of repeated administration of cord blood nucleated cells. Journal of Luhansk Taras Shevchenko National University (Biological sci.) 2014; 12(Part 1): 14–22.
Musina R.A., Bekchanova E.S., Belyavsky A.V. et al. Mesenchymal stem cells of umbilical blood. Cell Technologies in Biology and Medicine 2007; (1): 16–20.
Newman M.B., Willing A.E., Manressa J.J. et al. Cytokines produced by cultured human umbilical cord blood (HUCB) cells: implications for brain repair. Exp Neurol 2006; 199(1): 201–208. CrossRef PubMed
Nikolic W.V., Hou H., Town T. et al. Peripherally administered human umbilical cord blood cells reduce parenchymal and vascular beta–amyloid deposits in Alzheimer mice. Stem Cells Develop 2008; 17(1): 1–17.
Paltsev M.A., Sukhikh G.T., Smirnov V.N. Therapeutic potential of cord blood stem cells (neurology and psychiatry). Russian Medical News 2009; 14(2): 84–86.
Perdikogianni C., Dimitriou H., Stiakaki E. Could cord blood be a source of mesenchymal stromal cells for clinical use? Cytotherapy 2008; 10(5): 452–459. CrossRef PubMed
Petrenko A.Yu., Khunov Yu.A., Ivanov E.N. Stem cells. Features and prospects for clinical application. Lugansk; 2011.
Romanov Y.A., Svintsitskaya V.A., Smirnov V.N. Searching for alternative sources of postnatal human mesenchymal stem cells: candidate MSC–like cells from umbilical cord. Stem Cells 2003; 21(1): 105–110. CrossRef PubMed
Skvortsova V.I., Gubsky L.V., Tairova R.T. et al. Use of mesenchymal (stromal) bone marrow cells in experimental ischemic stroke in rats. Cell Technologies in Biology and Medicine 2008; (1): 14–20.
Smirnov V.N. Therapeutic potential of cord blood cells in neurological and psychiatric diseases. Proceedings of the IV International Symposium on Actual Issues in Cellular Technologies. Moscow; 2011: p. 11–17.
Smolyaninov A.B., Khurtsilava O.G., Tyrenko V.V. et al. Current strategy in regenerative therapy and application safety of allogeneic stem cells of cord blood in neurodegenerative diseases. Cellular Transplantology and Tissue Engineering 2011; 6(4): 14–20.
Sokolova I.B., Fedotova O.R., Zinkova N.N. et al. Effect of mesenchymal stem cell transplantation on cognitive function in rats with stroke. Bull Exp Biol Med 2006; 142(4): 511–514. CrossRef PubMed
Solovieva A.O., Poveschenko A.F., Poveschenko O.B. et al. Comparative study of migration and distribution of bone marrow and spleen donor cells into lymphoid and non–lymphoid organs in different terms after transplantation in vivo in CBA mice. Bulletin of Siberian Branch of Russian Academy of Medical Sciences 2013; 33(4): 35–41.
Surkov K.G., Belova L.A., Krasnyakov V.K. Experimental study of anti-ischemic effect of cord blood stem cell preparations. Proceeding of British-Russian Meeting on Cooperation with the European Commission "Stem Cells: Policy, Research and Innovation. International Prospects of Cooperation" (2007 March 15). Available from: URL: http://www.cbio.ru/modules/mydownloads/visit.php?lid=73.
Tsutsayeva A.A., Grischenko V.I., Kudokotseva O.V. et al. Cryopreservation of hematopoietic stem cells from human cord blood. Problems of Cryobiology 2000; (1): 59–63.
Tsutsayeva A.A., Grischenko V.I., Tsyganenko A.Ya. et al. Experience of clinical application of Gemokord preparation. Exp Clin Med 2005; (3): 104–107.
Tsyb A.F., Roshal L.M., Yushakov V.V. et al. The morphofunctional study of therapeutic effect of autologous mesenchymal stem cells in experimental diffuse brain damage in rats. Bull Exp Biol Med 2006; 142(1): 140–147. CrossRef PubMed
Tsymbalyuk V.I., Medvedev V.V. Neurogenic stem cells. Kiev: Koval; 2005. PubMed
Sanchez-Ramos J.R, Song S., Kamath S.G. et al. Expression of neural markers in human umbilical cord blood. Exp Neurol 2001; 171(1): 109–115. CrossRef PubMed
Sun T., Ma Q.-H. Repairing neural injuries using human umbilical cord blood. Mol Neurobiol 2013; 47(3): 938–945. CrossRef PubMed
Taguchi A., Soma T., Tanaka H. et al. Administration of CD34+ cells after stroke enhances neurogenesis via angiogenesis in a mouse model. J Clin Invest 2004; 114(2): 330–338. CrossRef PubMed
Uccelli A., Prockop D.J., Why should mesenchymal stem cells (MSCs) cure autoimmune diseases? Curr Opin Immunol 2010; 22(6): 768–774. CrossRef PubMed
Vendrame M., Cassady J., Newcomb J. et al. Infusion of human umbilical cord blood cells in a rat model of stroke dose dependently rescues behavioral deficits and reduces infarct volume. Stroke 2006; (35): 2390–2395.
Vladimirskaya E.B., Mayorova O.A., Rumyantsev S.A. et al. Biological grounds and prospects of stem cell therapy. Moscow: Medpraktika; 2005.
Willing A.E., Lixian J., Milliken M. et al. Intravenous versus intrastriatal cord blood administration in a rodent model of stroke. J Neurosci Res 2003; 73(3): P. 296–307. CrossRef PubMed
Xiao J., Iman Z., Motooka Y., Low W.C. Transplantation of a novel cell line population of umbilical cord blood stem cells ameliorates neurological deficits associated with ischemic brain injury. Stem Cells Dev 2005; 14(6): 722–733. CrossRef PubMed
Yarygin K.N., Semchenko V.V., Ereniyev S.I. et al. Regenerative biology and medicine. In: Yarygin V.N, editor. Book II. Cell technology in therapy of nervous diseases. Yekaterinburg – Moscow – Omsk – Tomsk – Khanty-Mansiysk; 2015: P. 360.
Yi T., Song SU. Immunomodulatory properties of mesenchymal stem cells and their therapeutic applications. Arch Pharm Res 2012; 35(2): 213–221. CrossRef PubMed
Zarrabi M., Mousavi S.H., Abroun S., Sadeghi B. Potential uses for cord blood mesenchymal stem cells. Cell J (Yakhteh) 2014; 15(4): 274–281.
Zigova T., Song S., Willing A.E. et al. Human umbilical cord blood cells express neural antigens after transplantation into the developing rat brain. Cell Transplant 2002; 11(3): 265–274. PubMed
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Copyright (c) 2020 Viktoria S. Aidarova, Olga V. Kudokotseva, Ivan I. Lomakin, Georgiy A. Babijchuk
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