Immunological Traits of Cryoablation in Combination Therapy of Cancer

  • Anatoliy M. Goltsev Institute for Problems of Cryobiology and Cryomedicine of the National Academy of Sciences of Ukraine, Kharkiv
  • Mykola O. Bondarovych Institute for Problems of Cryobiology and Cryomedicine of the National Academy of Sciences of Ukraine, Kharkiv
  • Tatiana G. Dubrava Institute for Problems of Cryobiology and Cryomedicine of the National Academy of Sciences of Ukraine, Kharkiv
  • Natalya M. Babenko Institute for Problems of Cryobiology and Cryomedicine of the National Academy of Sciences of Ukraine, Kharkiv
  • Yuliya O. Gaevska Institute for Problems of Cryobiology and Cryomedicine of the National Academy of Sciences of Ukraine, Kharkiv
  • Maksim V. Ostankov Institute for Problems of Cryobiology and Cryomedicine of the National Academy of Sciences of Ukraine, Kharkiv
  • Iryna A. Buriak Institute for Problems of Cryobiology and Cryomedicine of the National Academy of Sciences of Ukraine, Kharkiv
Keywords: cryoablation, cancer stem cells, immune system, antigen, dendritic cells

Abstract

Cryoablation is a method of choice in treatment of solid tumors of different localization. In addition to the destruction of pathological tissue, the cryoablation causes to complex changes in the immune system. This paper briefly discusses the implementation of the abscopic effect after cryosurgery of tumors, as well as possible changes in the immune system that accompany it. The abscopic effect is achieved with a release of antigens from the destroyed cells, which trigger a cascade of immune reactions. This article summarizes the results of the combined use of cryoablation and immunotherapeutic methods, in particular adoptive therapy. The introduction of dendritic cells in combination with cryoablation can significantly enhance antitumor immunity and reduces the risk of relapse.

 

Probl Cryobiol Cryomed 2019; 29(4): 297-302

Author Biographies

Anatoliy M. Goltsev, Institute for Problems of Cryobiology and Cryomedicine of the National Academy of Sciences of Ukraine, Kharkiv
Department of Cryopathophysiology and Immunology
Mykola O. Bondarovych, Institute for Problems of Cryobiology and Cryomedicine of the National Academy of Sciences of Ukraine, Kharkiv
Department of Cryopathophysiology and Immunology
Tatiana G. Dubrava, Institute for Problems of Cryobiology and Cryomedicine of the National Academy of Sciences of Ukraine, Kharkiv
Department of Cryopathophysiology and Immunology
Natalya M. Babenko, Institute for Problems of Cryobiology and Cryomedicine of the National Academy of Sciences of Ukraine, Kharkiv
Department of Cryopathophysiology and Immunology
Yuliya O. Gaevska, Institute for Problems of Cryobiology and Cryomedicine of the National Academy of Sciences of Ukraine, Kharkiv
Department of Cryopathophysiology and Immunology
Maksim V. Ostankov, Institute for Problems of Cryobiology and Cryomedicine of the National Academy of Sciences of Ukraine, Kharkiv
Department of Cryopathophysiology and Immunology
Iryna A. Buriak, Institute for Problems of Cryobiology and Cryomedicine of the National Academy of Sciences of Ukraine, Kharkiv
Department of Cryomicrobiology

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Published
2019-12-17
How to Cite
Goltsev, A. M., Bondarovych, M. O., Dubrava, T. G., Babenko, N. M., Gaevska, Y. O., Ostankov, M. V., & Buriak, I. A. (2019). Immunological Traits of Cryoablation in Combination Therapy of Cancer. Problems of Cryobiology and Cryomedicine, 29(4), 297-302. https://doi.org/10.15407/cryo29.04.297