Change in Strain-Strength Indices of Extracellular Matrix After Its Decellularization

Authors

  • Andrey G. Popandopulo V.K. Gusak Institute of Urgent and Reconstructive Surgery of National Academy of Medical Sciences of Ukraine, Donetsk, Ukraine
  • Marina V. Savchuk V.K. Gusak Institute of Urgent and Reconstructive Surgery of National Academy of Medical Sciences of Ukraine, Donetsk, Ukraine
  • Dmitriy L. Yuditsky M. Gorky Donetsk National Medical University, Donetsk, Ukraine

DOI:

https://doi.org/10.15407/cryo24.04.346

Keywords:

tissue engineering, graft, decellularization, extracellular matrix, strength

Abstract

Tissue-engineered grafts of valves are current solution of prostheses medical problem and able of proper substituting the mechanical valvular prostheses. These prostheses are based on using decellularized connective tissue matrix. The research was aimed to design extracellular matrix close to native on morphological and physical properties after decellularization to create valvular-vascular biological graft. The research results demonstrated that the tissue strain and strength were preserved and therefore the matrix could be used as a scaffold for prostheses.


Probl Cryobiol Cryomed 2014; 24(4):346-353.

References

Avtonomova L.V., Dergun S.M., Goncharova G.A., Stepchuk A.V. Mechanical trials on strain and internal pressure of grafts' vessels: Proc. of the reports. Vestnik NTU 'KhPI' 2009; (30): 3–7.

Badylak S.F., Weiss D.J., Caplan A., Macchiarini P. Engineered whole organs and complex tissues. Lancet 2012; 379(9819): 943–952. CrossRef

Grauss R.W., Hazekamp M.G., van Vliet S. et al. Decellularization of rat aortic valve allografts reduces leaflet destruction and extracellular matrix remodeling. J Thorac Cardiovasc Surg 2003: 126(6): 2003–2010. CrossRef

Kurapeyev D.I., Lavreshin A.V., Anisimov S.V. Tissue engineering of heart valves: decellularization of allo- and xenografts. Cell Transplantology and Tissue Engineering 2012; 7(1): 34–39.

Lam M.T., Wu J.C. Biomaterial applications in cardiovascular tissue repair and regeneration. Expert Rev Cardiovasc Ther 2012; 10(8): 1039–1049. CrossRef PubMed

Rabkin-Aikawa E., Farber M., Aikawa M., Schoen F.J. Dynamic and reversible changes of interstitial cell phenotype during remodeling of cardiac valves. J Heart Valve Dis 2004; 13(5): 841–847. PubMed

Robinson K.A., Li J., Mathison M., Redkar A. et al. Extracellular matrix scaffold for cardiac repair. Circulation 2005; 112 (9): 135–143.

Samusev R.P., Smirnov A.V. Atlas in cytology, histology and embryology. – Moscow: JSC "Mir i Obrazovanie" Publishing House, 2006; 66–69.

Sandomirsky B.P., Byzov D.V., Mikhaylova I.P. New approach when designing vascular prostheses of small diameter. In: Actual problems of cryobiology and cryomedicine. Kharkov; 2012. p. 623–654.

Schmidt D., Hoerstrup S.P. Tissue engineered heart valves based on human cells. Swiss Med Wkly 2007; 137(155): 80S–85S. PubMed

Schmidt D., Stock U.A., Hoerstrup S.P. Tissue engineering of heart valves using decellularized xenogeneic or polymeric starter matrices. Philos Trans R Soc Lond B Biol Sci 2007; 362(1484): 1505–1512. CrossRef PubMed

Schoen F.J. Evolving concepts of cardiac valve dynamics: the continuum of development, functional structure, pathobiology, and tissue engineering. Circulation 2008; 118(18): 1864–1880. CrossRef PubMed

Steinhoff G., Stock U., Karim N. et al. Tissue engineering of pulmonary heart valves on allogenic acellular matrix conduits: in vivo restoration of valve tissue. Circulation 2000; 102(19): 50–55. CrossRef

Taganovich A.D., Kukhta V.K., Morozkina T.S. et al. Biological chemistry: brief lecture course for foreign students of dentistry faculty. Minsk: 2005.

Tudorache I., Cebotari S., Sturz G. et al. Tissue engineering of heart valves: biomechanical and morphological properties of decellularized heart valves. J Heart Valve Dis 2007; 16(5): 567–573. PubMed

Vesely I. Heart Valve Tissue Engineering. Circ Res 2005: 97(8): 743–755. CrossRef PubMed

Volova T.G., Shishatskaya E.I., Mironov P.V. Materials for medicine, cell and tissue engineering. Krasnoyarsk: SFU, 2009; 168–170.

Weber K.T., Sun Y., Tyagi S.C., Cleutjens J.P. Collagen network of the myocardium: function, structural remodeling and regulatory mechanisms. J Mol Cell Cardiol 1994; 26(3): 279–292. CrossRef PubMed

Yarilin A.A., Ignatieva G.A., Guschin I.S. et al. Actual problems of pathophysiology. Moscow: Meditsyna; 2001.

Wilson E.M., Spinale F.G. Myocardial remodelling and matrix metalloproteinases in heart failure: turmoil within the interstitium. Ann Med 2001; 33(9): 623–634. CrossRef

Yannas I.V., Tzeranis D.S., Harley B.A., So P.T. Biologically active collagen-based scaffolds: advances in processing and characterization. Philos Trans A Math Phys Eng Sci 2010; 368(1917): 2123–2139. CrossRef PubMed

Zhai W., Zhang H., Wu C., Zhang J. et al. Crosslinking of saphenous vein ECM by procyanidins for small diameter blood vessel replacement. J Biomed Mater Res B Appl Biomater 2014; 102(5): 936–949. CrossRef

Zhou J., Hu S., Ding J. et al. Tissue engineering of heart valves: PEGylation of decellularized porcine aortic valve as a scaffold for in vitro recellularization. Biomed Eng Online 2013; 12: 87. CrossRef PubMed

Downloads

Published

2014-12-20

How to Cite

Popandopulo, A. G., Savchuk, M. V., & Yuditsky, D. L. (2014). Change in Strain-Strength Indices of Extracellular Matrix After Its Decellularization. Problems of Cryobiology and Cryomedicine, 24(4), 346–353. https://doi.org/10.15407/cryo24.04.346

Issue

Section

Cryomedicine, Clinical and Experimental Transplantology