COVID–19 – потенційна мішень для кріобіології і кріомедицини
DOI:
https://doi.org/10.15407/cryo30.02.107Ключові слова:
SARS-CoV-2, COVІD-19, імунна ÑиÑтема, кріоконÑервований лейкоконцентрат кордової крові людини, противіруÑний захиÑÑ‚Анотація
У огляді представлено дані щодо імунопатогенезу COVІD-19 і підходів до його профілактики та лікування. Низька ефективність противірусних засобів обумовлена здатністю вірусу SARS-CoV2 до зміни власних структурних і функціональних характеристик. Існуючі стратегії лікування COVІD-19 сфокусовані на застосуванні лікувальних засобів прямої противірусної дії, модуляції вродженої імунної відповіді, пригніченні «цитокінового шторму» та застосуванні плазми реконвалесцентів. Дизрегуляція взаємодії систем вродженого та адаптивного імунітету обумовлює запуск аутоімунного процесу в організмі вірусоносія, що потребує застосування альтернативних підходів до профілактики таких захворювань із використанням кріобіологічних технологій. Наведено результати вивчення імунобіологічної активності кріоконсервованого лейкоконцентрату кордової крові людини (кЛККЛ) і його компонентів за превентивного інтраназального введення. Ефективність застосування кЛККЛ пов’язана з можливістю перепрограмування генів, відповідальних за реалізацію імунних відповідей організму та індукцію «тренованого» імунітету. Така модифікація стану імунної системи може бути найбільш перспективною у забезпеченні захисту організму від вірусів, зокрема COVІD-19.
Probl Cryobiol Cryomed 2020; 30(2): 107–131
Посилання
Amiral J, Vissac AM, Seghatchian J. Covid-19, induced activation of hemostasis, and immune reactions: Can an auto-immune reaction contribute to the delayed severe complications observed in some patients? Transfus Apher Sci. [Internet]. 2020 May 3[cited 2020 May 15]:102804. Available from: https://www.sciencedirect.com/science/article/pii/S1473050220300999?via%3Dihub CrossRef
Ankrum JA, Ong JF, Karp JM. Mesenchymal stem cells: immune evasive, not immune privileged. Nat Biotechnol. 2014; 32(3): 252-60. CrossRef
Armitage J, Tan DBA, Troedson R, et al. Mesenchymal stromal cell infusion modulates systemic immunological responses in stable COPD patients: a phase I pilot study. Eur Respir J [Internet]. 2018 Mar 1 [cited 2020 May 15]; 51(3):1702369. Available from: https://erj.ersjournals.com/content/51/3/1702369.long CrossRef
Arnaud CH. Adding the missing sugars to coronavirus protein structures. Chemical & Engineering News. 2020; 98(6): 24-5. CrossRef
Arts RJW, Moorlag SJCFM, Novakovic B, et al. BCG vaccination protects against experimental viral infection in humans through the induction of cytokines associated with trained immunity. Cell Host Microbe [Internet]. 2018 Jan 10 [cited 2020 May 15]; 23(1): 89-100. Available from: https://www.sciencedirect.com/science/article/pii/S1931312817305462?via%3Dihub CrossRef
Babaeva AG. [Past, present, and future problems in lymphoid regulation of nonlymphoid cell proliferation]. Biull Eksp Biol Med. 1995; 120(9):230-4. Russian. CrossRef
Berkhout B. RNAi-mediated antiviral immunity in mammals. Curr Opin Virol. 2018; 32: 9-14. CrossRef
Bertram S, Glowacka I, Muller MA, et al. Cleavage and activation of the severe acute respiratory syndrome coronavirus spike protein by human airway trypsin-like protease. J Virol. 2011; 85(24): 13363-72. CrossRef
Dandekar AA, Perlman S. Immunopathogenesis of coronavirus infections: implications for SARS. Nat Rev Immunol. 2005; 5(12): 917-27. CrossRef
Darwish I, Banner D, Mubareka S, et al. Mesenchymal stromal (stem) cell therapy fails to improve outcomes in experimental severe influenza. PLoS One. [Internet]. 2013 Aug 15 [cited 2020 May 15]; 8(8): e71761. Available from: https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0071761 CrossRef
DeDiego ML, Nieto-Torres JL, Jimenez-GuardeÑo JM, et al. Coronavirus virulence genes with main focus on SARS-CoV envelope gene. Virus Res. 2014; 194: 124-37. CrossRef
Delgado-Rochea L, Mestab F. Oxidative stress as key player in severe acute respiratory syndrome coronavirus (SARS-CoV) infection. Archives of Medical Research. 2020; 51(5): 384–7. CrossRef
Drannik GN. [Clinical immunology and allergology]. Odessa: Astro-print; 1999. 601 p. Russian.
Eggenhofer E, Benseler V, Kroemer A, et al. Mesenchymal stem cells are short-lived and do not migrate beyond the lungs after intravenous infusion. Front Immunol. [Internet]. 2012 Sep 26 [cited 2020 May 15]; 3: 297. Available from: https://www.frontiersin.org/articles/10.3389/fimmu.2012.00297/full CrossRef
Esfandiyari R, Halabian R, Behzadi E, et al. Performance evaluation of antimicrobial peptide ll-37 and hepcidin and в-defensin-2 secreted by mesenchymal stem cells. Heliyon. [Internet]. 2019 Oct 23 [cited 2020 May 15];5(10): e02652. Available from: https://www.sciencedirect.com/science/article/pii/S2405844019363121?via%3Dihub CrossRef
Fan H, Yang J, Hao J, et al. Comparative study of regulatory T cells expanded ex vivo from cord blood and adult peripheral blood. Immunology. 2012; 136(2): 218-30. CrossRef
Ferrara JL, Abhyankar S, Gilliland DG. Cytokine storm of graft-versus-host disease: a critical effector role for interleukin-1. Transplant Proc. 1993; 25(1 Pt 2): 1216-7. PubMed
Foronjy RF, Dabo AJ, Cummins N, Geraghty P. Leukemia inhibitory factor protects the lung during respiratory syncytial viral infection. BMC Immunology. [Internet]. 2014 Oct 3 [cited 2020 May 15]; 15: 41. Available from: http://www.biomedcentral.com/1471-2172/15/41 CrossRef
Frieman MB, Chen J, Morrison TE, et al. SARS-CoV pathogenesis is regulated by a STAT1 dependent but a type I, II and III interferon receptor independent mechanism. PLoS Pathog. [Internet]. 2010 Apr 8 [cited 2020 May 15]; 6(4): e1000849. Available from: https://journals.plos.org/plospathogens/article?id=10.1371/journal.ppat.1000849 CrossRef
Fuller BJ. Gene expression in response to low temperatures in mammalian cells: a review of current ideas. Cryo Letters. 2003; 24(2):95-102. PubMed
Goltsev AM, Babenko NM, Gaevska YuO, et al. Immunoregulatory effect of mouse fetal neural cells on the graft-versus-host disease. Cell and Organ Transplantology. 2019; 7(1): 40-6. CrossRef
Goltsev AM, Dubrava TG, Lutsenko OD, et al. [Molecular mechanisms of immune correcting effect of cell therapy under development of autoimmune diseases]. Odes'kyi Medychnyi Zhurnal. 2013; (4): 13-8. Ukranian.
Goltsev AM, Tarannik GK, Grisha IG, et al. inventors; Institute for Problems of Cryobiology and Cryomedicine, assignee. [Method of lyophilization of leukoconcentrate of cord blood]. Patent of Ukraine â„– 113006, 2017 Jan 10. Ukranian.
Goltsev AN. [Probable causes of the development of autoimmune pathology and search for the ways of its treatment]. Probl Med Nauki ta Osvity. 2000; (1): 22-37. Russian.
Goltsev AN, Bondarovych NA, Dubrava TG, et al. Immunological traits of cryoablation in combination therapy of cancer. Probl Cryobiol Cryomed. 2019; 29(4): 297-302. CrossRef
Goltsev AN, Dubrava TG, Lutsenko ED, et al. [Manifestation of immune correcting effect of cryopreserved cells of fetal liver of different gestation terms under development conditions of experimental model of graft-versus-host reaction]. Genes & Cells. 2010; 5(3): 82-6. Russian.
Goltsev AN, Lutsenko ED, Dimitrov AYu, et al. Peculiarities of functional state modulation of genetic apparatus of fetal liver cells with stemness characteristics after cryopreservation. Cryo Letters. 2011; 32(6): 543-4.
Goltsev KA, Ovsyannikov SYe, Kozhina OYu, et al. Correction of metabolic impairments with 'Cryocell-Hemocord' cord blood preparation during acute purulent peritonitis. Problems of Cryobiology. 2011; 21(1): 96-103. Full Text
Grischenko VI, Goltsev AN. Transplantation of the products of embryofetoplacental complex from understanding of mechanism of the effect to increasing the efficiency of application. Problems of Cryobiology. 2002; (1): 54-84.
Hagemeijer MC, Monastyrska I, Griffith J, et al. Membrane rearrangements mediated by coronavirus nonstructural proteins 3 and 4. Virology. 2014; 458-459 (1): 125-35. CrossRef
Helmy YA, Fawzy M, Elaswad A, et al. The COVID-19 pandemic: a comprehensive review of taxonomy, genetics, epidemiology, diagnosis, treatment, and control. J Clin Med. [Internet]. 2020 Apr 24 [cited 2020 May 15]; 9(4): 1225. Available from: https://www.mdpi.com/2077-0383/9/4/1225 CrossRef
Hoffmann MH, Griffiths HR. The dual role of reactive oxygen species in autoimmune and inflammatory diseases: evidence from preclinical models. Radic Biol Med. 2018; 125: 62-71. CrossRef
Katkov II, Kima MS, Bajpaic R. Cryopreservation by slow cooling with DMSO diminished production of Oct-4 pluripotency marker in human embryonic stem cells. Cryobiology. 2006; 53 (2): 194−205. CrossRef
Khoury M, Cuenca J, Cruz FF, et al. Current status of cell-based therapies for respiratory virus infections: applicability to COVID-19. Eur Respir J [Internet]. 2020 Jun 4 [cited 2020 Jun 15]; 55(6): 2000858. Available from:https://erj.ersjournals.com/content/55/6/2000858 CrossRef
Kienhofer D, Boeltz S, Hoffmann MH. Reactive oxygen homeostasis - the balance for preventing autoimmunity. Lupus. 2016; 25(8): 943-54. CrossRef
Kindler E, Thiel V, Weber F. Interaction of SARS and MERS coronaviruses with the antiviral interferon response. Adv Virus Res. 2016; 96: 219-43. CrossRef
Kobasa D, Jones SM, Shinya K, et al. Aberrant innate immune response in lethal infection of macaques with the 1918 influenza virus. Nature. 2007; 445(7125): 319-23. CrossRef
Kopecky-Bromberg SA, Martinez-Sobrido L, Frieman M, et al. Severe acute respiratory syndrome coronavirus open reading frame (ORF) 3b, ORF 6, and nucleocapsid proteins function as interferon antagonists. J Virol. 2007; 81(2): 548-57. CrossRef
Koval GK, Lutsenko OD, Grisha IG, et al. Impact of lyophilisation on integrity of structural and functional characteristics of human cord blood leukoncentrate. Probl Cryobiol Cryomed. 2019; 29(4): 332-43. CrossRef
Kozhyna OYu, Ostankov MV, Grisha IG, et al. [Application of cryopreserved human cord blood leucoconcentrat for prophylactic of influenza (experimental research)]. Eksperymental'na i Klinichna Medytsyna. 2012; (4): 16-21. Russian.
Kozhina OYu, Ostankov MV, Ostankova LV, et al. Effect of cryopreserved cord blood on activity of alveolar macrophages in experimental model of influenza. Probl Cryobiol Cryomed. 2013; 23(3): 247-59. Full Text
Kurien BT, Scofield RH. Autoimmunity and oxidatively modified autoantigens. Autoimmun Rev. 2008; 7(7): 567-73. CrossRef
Lee CC, Lin SJ, Cheng PJ, Kuo ML. The regulatory function of umbilical cord blood CD4(+) CD25(+) T cells stimulated with anti-CD3/anti-CD28 and exogenous interleukin (IL)-2 or IL-15. Pediatr Allergy Immunol. 2009; 20(7):624-32. CrossRef
Leng Z, Zhu R, Hou W, et al. Transplantation of ACE2 - mesenchymal stem cells improves the outcome of patients with COVID-19 pneumonia. Aging Dis. 2020; 11(2): 216-28. CrossRef
Leung HN. Mechanism of antibody-dependent enhancement in severe acute respiratory syndrome coronavirus infection: thesis for the degree of Master of Philosophy [dissertation on the internet]. Hong Kong: University of Hong Kong; 2012. 139p. [cited 2020 May 16] Available from: http://hub.hku.hk/handle/10722/174389
Li G, Fan Y, Lai Y, et al. Coronavirus infections and immune responses. J Med Virol. 2020; 92(4): 424-32. CrossRef
Li X, Geng M, Peng Y, et al. Molecular immune pathogenesis and diagnosis of COVID-19. J Pharm Anal. 2020; 10(2): 102-8. CrossRef
Lutsenko ED, Ostankov MV, Dimitrov AYu, Goltsev AN. [Selection of cryopreservation mode of placenta cells determines its immunological properties]. Biofizika Zhivoi Kletki. 2014; 10: 120-2. Russian.
Lutsenko OD, Ostankova LV, Ostankov MV, et al. [Features of changes in the phenotype of human cord blood leukoconcentrate after cryopreservation and lyophilization]. In: Proceedings of the VIII National Congress of Pathophysiologists of Ukraine 'Pathological physiology - health care of Ukraine'; 2020 March 13-15 Odesa, Ukraine. Odesa; 2020. p. 35. Ukrainian.
Lyons-Weiler J. Pathogenic priming likely contributes to serious and critical illness and mortality in COVID-19 via autoimmunity. J Transl Autoimmun. [Internet]. 2020 Apr 9 [cited 2020 May 15]; 3:100051. Available from:https://www.sciencedirect.com/science/article/pii/S2589909020300186 CrossRef
Malha L, Mueller FB, Pecker MS, et al. COVID-19 and the renin-angiotensin system. Kidney Int Rep. 2020; 5(5): 563-5. CrossRef
Mandic Havelka A, Yektaei-Karin E, Hultenby K, et al. Maternal plasma level of antimicrobial peptide LL37 is a major determinant factor of neonatal plasma LL37 level. Acta Paediatr. 2010; 99(6): 836-41. CrossRef
Maringer K, Fernandez-Sesma A. Message in a bottle: lessons learned from antagonism of STING signalling during RNA virus infection. Cytokine Growth Factor Rev. 2014; 25(6): 669-79. CrossRef
Marquez-Curtis LA, Janowska-Wieczorek A. Enhancing the migration ability of mesenchymal stromal cells by targeting the SDF-1/CXCR4 axis. Biomed Res Int. [Internet]. 2013[cited 2020 May 15]; 2013: 561098. Available from: https://www.hindawi.com/journals/bmri/2013/561098/ CrossRef
Miller A, Reandelar MJ, Fasciglione K, et al. Correlation between universal BCG vaccination policy and reduced morbidity and mortality for COVID-19: an epidemiological study. (Preprint) medRxiv [Internet]. 28 March 2020 [cited 2020 May 15]; 20042937 Available from: https://www.medrxiv.org/content/10.1101/2020.03.24.20042937v1 CrossRef
Noronha NC, Mizukami A, Caliari-Oliveira C, et al. Priming approaches to improve the efficacy of mesenchymal stromal cell-based therapies. Stem Cell Res Ther. [Internet]. 2019 May 2 [cited 2020 May 15]; 10(1): 131. Available from: https://stemcellres.biomedcentral.com/articles/10.1186/s13287-019-1224-y CrossRef
Olson JK, Croxford JL, Miller SD. Virus-induced autoimmunity: potential role of viruses in initiation, perpetuation, and progression of T-cell-mediated autoimmune disease. Viral Immunol. 2001; 14(3): 227-50. CrossRef
Onasenko YeS, Brovko YeV, Volina VV, Ponomareva VL. Infection of animals with the influenza virus after a preliminary administration of the preparation 'Cryocell-Haemocord'. Report I. Investigation of functional activity of murine immunocompetent organs. Problems of Cryobiology. 2010; 20(1): 99-105. Full Text
Paludan SR. Innate antiviral defenses independent of inducible IFNα/β production. Trends Immunol. 2016; 37(9): 588-96. CrossRef
Qin C, Zhou L, Hu Z, et al. Dysregulation of immune response in patients with COVID-19 in Wuhan, China. Clin Infect Dis. [Internet]. 2020 Mar 12 [cited 2020 May 15]; ciaa248. Available from: https://academic.oup.com/cid/advance-article/doi/10.1093/cid/ciaa248/5803306. CrossRef
Regmi S, Pathak S, Kim JO, et al. Mesenchymal stem cell therapy for the treatment of inflammatory diseases: Challenges, opportunities, and future perspectives. Eur J Cell Biol. [Internet]. 2019 December [cited 2020 May 15];98(5-8): 151041. Available from: https://www.sciencedirect.com/science/article/pii/S0171933519300378?via%3Dihub CrossRef
Reid AH, Fanning TG, Hultin JV, Taubenberger JK. Origin and evolution of the 1918 'Spanish' influenza virus hemagglutinin gene. Proc Natl Acad Sci USA. 1999; 96(4): 1651-6. CrossRef
Reinholz M, Ruzicka T, Schauber J. Cathelicidin LL-37: an antimicrobial peptide with a role in inflammatory skin disease. Ann Dermatol. 2012; 24(2): 126-35. CrossRef
Rusek P, Wala M, DruszczyÑska M, Fol M. Infectious agents as stimuli of trained innate immunity. Int J Mol Sci [Internet]. 2018 Feb 3 [cited 2020 May 15]; 19(2): E456. Available from: https://www.mdpi.com/1422-0067/19/2/456 CrossRef
Sakaguchi S, Mikami N, Wing J B, et al. Regulatory T cells and human disease. Annu Rev Immunol, 2020; 38:541-66. CrossRef
Schoeman D, Fielding BC. Coronavirus envelope protein: current knowledge. Virol J [Internet]. 2019 May 27 [cited 2020 May 15]; 16(1): 69. Available from: https://virologyj.biomedcentral.com/articles/10.1186/s12985-019-1182-0 CrossRef
Scott MG, Davidson DJ, Gold MR, et al. The human antimicrobial peptide LL-37 is a multifunctional modulator of innate immune responses. J Immunol. 2002; 169(7): 3883-91. CrossRef
Shi CS, Qi HY, Boularan C, et al. SARS-coronavirus open reading frame-9b suppresses innate immunity by targeting mitochondria and the MAVS/TRAF3/TRAF6 signalosome. J Immunol. 2014; 193(6): 3080-9. CrossRef
Siracusano G, Pastori C, Lopalco L. Humoral immune responses in COVID-19 patients: a window on the state of the art. Front Immunol [Internet]. 2020 10 May 15 [cited 2020 May 15]; 11: 1049. Available from: https://www.frontiersin.org/articles/10.3389/fimmu.2020.01049/full CrossRef
Soliman R, Brassey J, Pluddemann A, et al. Does BCG vaccination protect against acute respiratory infections and COVID-19? A rapid review of current evidence. The Centre for Evidence-Based Medicine [Internet]. 2020 April 24 [cited 2020 May 15]. Available from: https://www.cebm.net/covid-19/does-bcg-vaccination-protect-against-acute-respiratory-infections-and-covid-19-a-rapid-review-of-current-evidence/
Stetsyshyn VG, Ostankova LV, Gaevskaya YuA, et al. [Immune correcting of genital herpes with cryopreserved cord blood (experimental study)]. Medytsyna Sogodni i Zavtra. 2015. 69 (4): 56-62. Russian.
Takakia H, Ichimiyab S, Matsumotoa M, Seyaa T. Mucosal immune response in nasal associated lymphoid tissue upon intranasal administration by adjuvants. J Innate Immun. 2018; 10 (5-6): 515-21. CrossRef
Tay MZ, Poh CM, Renia L, et al. The trinity of COVID-19: immunity, inflammation and intervention. Nat Rev Immunol. 20(6): 363-74. CrossRef
Tetro J. Is COVID-19 receiving ADE from other coronaviruses? Microbes Infect. 2020; 22(2): 72-3. CrossRef
Thanunchai M, Kanrai P, Wiboon-Ut S, et al. Tropism of avian influenza A (H5N1) virus to mesenchymal stem cells and CD34+ hematopoietic stem cells. PLoS One. [Internet]. 2013 Dec 10 [cited 2020 May 15]; 8(12): e81805. Available from: https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0081805 CrossRef
Thorp HH. Both/and problem in an either/or world. Science. 2020; 368 (6492): 681. CrossRef
Tsivgoulis G, Fragkou PC, Delides A, et al. Quantitative evaluation of olfactory dysfunction in hospitalized patients with Coronavirus [2] (COVID-19). Neurol [Internet]. 2020 May 25 [cited 2020 May 27]: 1-3. Available from: https://link.springer.com/article/10.1007/s00415-020-09935-9 CrossRef
Tsutsayeva AA, Brovko EV, Zheltjakova IA, et al. [Leukoconcentrate of cord blood 'Hemocord'. Morphofunctional properties of the preparation before and after cryopreservation]. Nove v Gematologiyi ta Transfuziologiyi. Kyiv. 2006; (5): 99-103. Russian.
Tsutsayeva AA, Grischenko VI, Kudokotseva OV, et al. Cryopreservation of hematopoietic stem cells out of human cord blood. Problems of Cryobiology. 2000; (1): 59-63.
Tsutsayeva AA, Tsyganenko AYa, Zheltjakova IA, Pavlenko NV. [Methods for storing pathological material containing influenza virus]. Eksperymentalna i Klinichna Medytsyna. 2004; (2): 76-8. Russian.
Tsutsaieva AO, Hryshchenko VI, Onasenko OS, et al. inventors; Institute for Problems of Cryobiology and Cryomedicine, assignee. [Method for preventing respiratory viral infection]. Patent of Ukraine N 21484U, 2007 March 15. Ukrainian.
Tsutsayeva AA, Volina VV, Sokol LV, Zhulikov OA. Effect of human cord blood leukoconcentrate on skin regenerative activity in culture in vitro. Problems of Cryobiology. 2009; 19(1): 93-9. Full Text
Vankadari N, Wilce JA. Emerging WuHan (COVID-19) coronavirus: glycan shield and structure prediction of spike glycoprotein and its interaction with human CD26. Emerg Microbes Infect. 2020; 9(1): 601-4. CrossRef
Wang Q, Qiu Y, Li J-Y, et al. A unique protease cleavage site predicted in the spike protein of the novel pneumonia coronavirus (2019-nCoV) potentially related to viral transmissibility. Virol Sin [Internet]. 2020 Mar 20 [cited 2020 May 15]: 1-3. Available from: https://link.springer.com/article/10.1007/s12250-020-00212-7 CrossRef
Ward P, Higenbottam T, Gabbay F, et al. 'COVID-19 vaccine and antiviral drug development'. Faculty of pharmaceutical medicine blog [Internet]. 08 April 2020 [cited 2020 May 15]. Available from: https://www.fpm.org.uk/blog/covid-19-vaccine-and-antiviral-drug-development.
Watanabe Y, Berndsen ZT, Raghwani J, et al. Vulnerabilities in coronavirus glycan shields despite extensive glycosylation. Nat Commun [Internet]. 2020 May 27 [cited 2020 May 28]; 11(1): 2688. Available from: https://www.nature.com/articles/s41467-020-16567-0 CrossRef
Wei H, Li Z, Hu S, et al. Apoptosis of mesenchymal stem cells induced by hydrogen peroxide concerns both endoplasmic reticulum stress and mitochondrial death pathway through regulation of caspases, p38 and JNK. J Cell Biochem. 2010; 111(4): 967-78. CrossRef
Weiss SR, Navas-Martin S. Coronavirus pathogenesis and the emerging pathogen severe acute respiratory syndrome coronavirus. Microbiol Mol Biol Rev. 2005; 69 (4): 635-64. CrossRef
Wrapp D, Wang N, Corbett KS, et al. Cryo-EM structure of the 2019-nCoV spike in the prefusion conformation. Science. 2020; 367(6483): 1260-3. CrossRef
Wu R, Wang L, Kuo HD, et al. An update on current therapeutic drugs treating COVID-19. Curr Pharmacol Rep. 2020; 6: 56–70. CrossRef
Wu Z, McGoogan JM. Characteristics of and important lessons from the coronavirus disease 2019 (COVID-19) outbreak in china: summary of a report of 72 314 cases from the chinese center for disease control and prevention. JAMA. 2020; 323(13): 1239-42. CrossRef
Xu Z, Shi L, Wang Y, et al. Pathological findings of COVID-19 associated with acute respiratory distress syndrome. Lancet Respir Med. 2020; 8(4): 420-2. CrossRef
Yang TJ, Chang YC, Ko TP, et al. Cryo-EM analysis of a feline coronavirus spike protein reveals a unique structure and camouflaging glycans. Proc Natl Acad Sci U S A. 2020; 117(3): 1438-46. CrossRef
Yusuf H, Kett V. Current prospects and future challenges for nasal vaccine delivery. Hum Vaccin Immunother. 2017; 13(1):34-45. CrossRef
Zhang H, Zhou P, Wei Y, et al. Histopathologic changes and SARS-CoV-2 immunostaining in the lung of a patient with COVID-19. Ann Intern Med. 2020 May 5;172(9): 629-32. CrossRef
Zhou G, Zhao Q. Perspectives on therapeutic neutralizing antibodies against the Novel Coronavirus SARS-CoV-2. Int J Biol Sci. 2020;16(10): 1718-23. CrossRef
Ziegler CGK, Allon SJ, Nyquist SK, et al. SARS-CoV-2 receptor ACE2 is an interferon-stimulated gene in human airway epithelial cells and is detected in specific cell subsets across tissues. Cell. 2020; 181(5): 1016-35. CrossRef
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