МолекулÑрные оÑобенноÑти белков про- и Ñукариот, обладающих еÑтеÑтвенной адаптацией к низким температурам
DOI:
https://doi.org/10.15407/cryo25.03.219Ключевые слова:
Ñ…Ð¾Ð»Ð¾Ð´Ð¾Ð²Ð°Ñ Ð°Ð´Ð°Ð¿Ñ‚Ð°Ñ†Ð¸Ñ, низкие температуры, ферменты, Ñтруктурные белки, аминокиÑлоты, полÑрноÑÑ‚ÑŒ, гидрофобноÑÑ‚ÑŒАннотация
Ð’ работе оÑвещены результаты иÑÑледований молекулÑрных модификаций белков холодоадаптированных организмов. СоглаÑно имеющимÑÑ Ð´Ð°Ð½Ð½Ñ‹Ð¼ такие модификации доÑтигаютÑÑ Ð¿ÑƒÑ‚ÐµÐ¼ замены аминокиÑлотных оÑтатков в белковой молекуле, ÑÐ¾ÐºÑ€Ð°Ñ‰ÐµÐ½Ð¸Ñ Ñ‡Ð¸Ñла водородных ÑвÑзей и Ñолевых моÑтиков, ÑƒÐ¼ÐµÐ½ÑŒÑˆÐµÐ½Ð¸Ñ Ð³Ð¸Ð´Ñ€Ð¾Ñ„Ð¾Ð±Ð½Ð¾Ñти. Указанные модификации увеличивают гибкоÑÑ‚ÑŒ макромолекул, что обеÑпечивает их функциональноÑÑ‚ÑŒ. ОбÑуждаетÑÑ Ñ€Ð¾Ð»ÑŒ внутри-молекулÑрных взаимодейÑтвий в Ñтабилизации белков и их функциональном ÑоÑтоÑнии в диапазоне низких температур.
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